Document Detail


Protein synthesis is required for the generation of oscillatory current responses in Xenopus oocyte.
MedLine Citation:
PMID:  7980507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In Xenopus oocyte, direct activation of G-proteins by AIF4- or injection of inositol 1, 4, 5-trisphosphate evoked Ca(2+)-gated Cl-current responses. The current responses were smooth and not oscillatory when tested immediately after the oocyte was isolated. After hours of incubation, the response became oscillatory. This change was prevented by cycloheximide, a protein synthesis inhibitor. Results indicate that the characteristics of Ca2+ signaling system have changed from not oscillatory to oscillatory with time and protein synthesis was required for this change.
Authors:
Y Nakamachi; H Ando
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  204     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-30     Completed Date:  1994-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-11     Citation Subset:  IM    
Affiliation:
Department of Physiology, Kobe University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Aluminum Compounds / pharmacology
Animals
Calcium / metabolism*
Chloride Channels / physiology*
Fluorides / pharmacology
GTP-Binding Proteins / metabolism
Ion Channel Gating
Oocytes / drug effects,  physiology*
Protein Biosynthesis*
Receptors, Muscarinic / drug effects,  metabolism
Xenopus laevis
Chemical
Reg. No./Substance:
0/Aluminum Compounds; 0/Chloride Channels; 0/Fluorides; 0/Receptors, Muscarinic; 51-84-3/Acetylcholine; 7440-70-2/Calcium; 7784-18-1/aluminum fluoride; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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