| Protein-synthesis inhibition induces perichromatin granule accumulation and intranuclear rodlet formation in osmotically stimulated supraoptic neurons. | |
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MedLine Citation:
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PMID: 8512088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of perichromatin granules (PGs), a storage form of pre-mRNAs, was studied in supraoptic neurons of control and osmotically stimulated rats, and also after treatment with cycloheximide, a protein-synthesis inhibitor. In non-cycloheximide-treated rats, neuronal activation by dehydration significantly decreased the number of PGs. Conversely, PGs were drastically increased in the supraoptic neurons of dehydrated rats treated with cycloheximide for 4 h. This suggests that cycloheximide does not interfere with the transcriptional activation induced by dehydration, but it affects the processing of newly synthesized pre-mRNAs. Moreover, protein-synthesis inhibition was associated with the formation of intranuclear bundles of tubular filaments. |
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Authors:
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M Lafarga; M T Berciano; M A Andres |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anatomy and embryology Volume: 187 ISSN: 0340-2061 ISO Abbreviation: Anat. Embryol. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-07-15 Completed Date: 1993-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505194 Medline TA: Anat Embryol (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 363-9 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, Faculty of Medicine, Santander, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleus / drug effects, ultrastructure* Chromatin / drug effects, ultrastructure* Cycloheximide / pharmacology Male Microscopy, Electron Neurons / drug effects, ultrastructure* Rats Rats, Sprague-Dawley Sodium Chloride / pharmacology Supraoptic Nucleus / cytology, drug effects, ultrastructure* |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 66-81-9/Cycloheximide; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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