Document Detail

Protein synthesis and the components of protein synthetic machinery during cellular aging.
MedLine Citation:
PMID:  1722004     Owner:  NLM     Status:  MEDLINE    
The slowing down of protein synthesis is a change widely observed during the aging of organisms. It has also been claimed that a decline in the rate of protein synthesis occurs during cellular aging. However, the evidence in favour of this view is not clear-cut, and reliable estimates of rates of protein synthesis during cellular aging have yet to be made. Studies on various components of the protein synthetic machinery during cellular aging have revealed a decline in the efficiency and accuracy of ribosomes, an increase in the levels of rRNA and tRNA, and a decrease in the amounts and activities of elongation factors. Detailed studies on the structure and function of ribosomes, tRNA isoacceptor profiles, activities of aminoacyl-tRNA synthetases, levels and activities of initiation factors, rates of protein elongation, and the accuracy of protein synthesis will be needed before the molecular mechanisms of the regulation of protein synthesis during cellular aging can be understood.
S I Rattan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mutation research     Volume:  256     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:    1991 Mar-Nov
Date Detail:
Created Date:  1992-02-06     Completed Date:  1992-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  115-25     Citation Subset:  IM    
Laboratory of Cellular Aging, Department of Chemistry, Aarhus University, Denmark.
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MeSH Terms
Amino Acids / metabolism
Amino Acyl-tRNA Synthetases / metabolism
Cell Aging*
Peptide Elongation Factors / metabolism
Peptide Termination Factors / metabolism
Protein Biosynthesis*
RNA / metabolism
Ribosomes / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Peptide Elongation Factors; 0/Peptide Termination Factors; 63231-63-0/RNA; EC 6.1.1.-/Amino Acyl-tRNA Synthetases

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