| Protein synthesis and the components of protein synthetic machinery during cellular aging. | |
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MedLine Citation:
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PMID: 1722004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The slowing down of protein synthesis is a change widely observed during the aging of organisms. It has also been claimed that a decline in the rate of protein synthesis occurs during cellular aging. However, the evidence in favour of this view is not clear-cut, and reliable estimates of rates of protein synthesis during cellular aging have yet to be made. Studies on various components of the protein synthetic machinery during cellular aging have revealed a decline in the efficiency and accuracy of ribosomes, an increase in the levels of rRNA and tRNA, and a decrease in the amounts and activities of elongation factors. Detailed studies on the structure and function of ribosomes, tRNA isoacceptor profiles, activities of aminoacyl-tRNA synthetases, levels and activities of initiation factors, rates of protein elongation, and the accuracy of protein synthesis will be needed before the molecular mechanisms of the regulation of protein synthesis during cellular aging can be understood. |
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Authors:
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S I Rattan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Mutation research Volume: 256 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1991 Mar-Nov |
Date Detail:
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Created Date: 1992-02-06 Completed Date: 1992-02-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 115-25 Citation Subset: IM |
Affiliation:
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Laboratory of Cellular Aging, Department of Chemistry, Aarhus University, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Amino Acyl-tRNA Synthetases / metabolism Animals Cell Aging* Humans Peptide Elongation Factors / metabolism Peptide Termination Factors / metabolism Protein Biosynthesis* RNA / metabolism Ribosomes / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Peptide Elongation Factors; 0/Peptide Termination Factors; 63231-63-0/RNA; EC 6.1.1.-/Amino Acyl-tRNA Synthetases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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