| Protein synthesis, amino acid uptake, and pools during isoproterenol-induced hypertrophy of the rat heart and tibialis muscle. | |
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MedLine Citation:
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PMID: 6452942 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic administration of isoproterenol (ISO) produces hypertrophy of the rat heart and tibialis muscle. With doses of 0.1, 0.3, and 0.6 mg/kg, hypertrophy of the heart is significantly by the 3rd day of treatment. Maximum cardiac enlargement attained with doses of 0.3 and 0.6 mg/kg occurs after 21 days and averages 40% above control values. ISO increases tibialis muscle weight by 15%. Incorporation of 14C-labeled amino acids into total heart and tibialis muscle protein is stimulated by ISO. Maximum stimulation occurs 2-3 h after the fifth daily injection of ISO. The stimulation of incorporation is greater during the first few days of treatment and decreases gradually thereafter. A single injection of ISO decreases the total amino acid concentration of the serum, heart and tibialis muscle whereas the rate of amino acid uptake by the heart and tibialis muscle is increased by ISO. The production of hypertrophy of the heart and tibialis muscle in diabetic or castrated animals by ISO suggests that insulin and testosterone are not essential in the mechanism of ISO-induced hypertrophy. |
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Authors:
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Y Deshaies; J Willemot; J Leblanc |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 59 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-07-09 Completed Date: 1981-07-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 113-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Cardiomegaly / chemically induced, metabolism* Hypertrophy / metabolism Isoproterenol / pharmacology* Male Muscular Diseases / chemically induced, metabolism*, pathology Protein Biosynthesis* Rats Sex Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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