| Protein secretion pathways in Bacillus subtilis: implication for optimization of heterologous protein secretion. | |
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MedLine Citation:
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PMID: 16997527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The absence of an outer membrane in Bacillus subtilis can simplify the protein secretion pathways and allow the organism to secrete high levels of extracellular proteins. Of the three known secretory routes, Sec-SRP pathway can direct the majority of secretory proteins into the growth medium. Alternatively, a small number of exoproteins with specific functions are secreted via Tat pathway or ABC transporters in B. subtilis. The discriminating function of precursor proteins among these pathways is largely attributed to the distinct structure of their cleavable signal peptides. Individual secretion machinery components with their special functions are involved in the total flow of proteins from the cytoplasm to the medium. Notably, multiple regulators with signal transduction functions can affect expression of secretion machinery as well as their post-transcriptional actions for protein secretion, resulting in the complicated networks in B. subtilis. Ultimately, according to the available knowledge of secretion machinery, several approaches aimed at optimizing protein secretion are discussed. |
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Authors:
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Ling Lin Fu; Zi Rong Xu; Wei Fen Li; Jiang Bing Shuai; Ping Lu; Chun Xia Hu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-08-15 |
Journal Detail:
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Title: Biotechnology advances Volume: 25 ISSN: 0734-9750 ISO Abbreviation: Biotechnol. Adv. Publication Date: 2007 Jan-Feb |
Date Detail:
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Created Date: 2007-01-08 Completed Date: 2007-06-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8403708 Medline TA: Biotechnol Adv Country: England |
Other Details:
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Languages: eng Pagination: 1-12 Citation Subset: IM |
Affiliation:
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Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University (Hua Jia Chi Campus), Hangzhou 310029, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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metabolism Bacillus subtilis / metabolism* Bacterial Proteins / chemistry, secretion* Humans Metabolic Networks and Pathways Protein Transport Signal Recognition Particle |
| Chemical | |
Reg. No./Substance:
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0/ATP-Binding Cassette Transporters; 0/Bacterial Proteins; 0/Signal Recognition Particle |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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