Document Detail


Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.
MedLine Citation:
PMID:  20882600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices.
Authors:
Danielle A Guarracino; Brooke N Bullock; Paramjit S Arora
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Biopolymers     Volume:  95     ISSN:  0006-3525     ISO Abbreviation:  Biopolymers     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-02-03     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0372525     Medline TA:  Biopolymers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
2010 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Biomimetics
Biopolymers / chemistry*
Drug Design
Ligands
Protein Structure, Secondary
Proteins / antagonists & inhibitors,  chemistry*,  metabolism*
Transcription, Genetic
Grant Support
ID/Acronym/Agency:
GM073943/GM/NIGMS NIH HHS; HL094969/HL/NHLBI NIH HHS; R01 GM073943/GM/NIGMS NIH HHS; R01 GM073943-01/GM/NIGMS NIH HHS; R01 GM073943-01S1/GM/NIGMS NIH HHS; R01 GM073943-02/GM/NIGMS NIH HHS; R01 GM073943-03/GM/NIGMS NIH HHS; R01 GM073943-04/GM/NIGMS NIH HHS; R01 GM073943-05/GM/NIGMS NIH HHS; R01 GM073943-06/GM/NIGMS NIH HHS; R01 GM073943-07/GM/NIGMS NIH HHS; R21 HL094969/HL/NHLBI NIH HHS; R21 HL094969-01/HL/NHLBI NIH HHS; R21 HL094969-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biopolymers; 0/Ligands; 0/Proteins
Comments/Corrections

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