Document Detail

Protein oxidative damage at the crossroads of cellular senescence, aging, and age-related diseases.
MedLine Citation:
PMID:  23125894     Owner:  NLM     Status:  MEDLINE    
Protein damage mediated by oxidation, protein adducts formation with advanced glycated end products and with products of lipid peroxidation, has been implicated during aging and age-related diseases, such as neurodegenerative diseases. Increased protein modification has also been described upon replicative senescence of human fibroblasts, a valid model for studying aging in vitro. However, the mechanisms by which these modified proteins could impact on the development of the senescent phenotype and the pathogenesis of age-related diseases remain elusive. In this study, we performed in silico approaches to evidence molecular actors and cellular pathways affected by these damaged proteins. A database of proteins modified by carbonylation, glycation, and lipid peroxidation products during aging and age-related diseases was built and compared to those proteins identified during cellular replicative senescence in vitro. Common cellular pathways evidenced by enzymes involved in intermediate metabolism were found to be targeted by these modifications, although different tissues have been examined. These results underscore the potential effect of protein modification in the impairment of cellular metabolism during aging and age-related diseases.
Martin A Baraibar; Liang Liu; Emad K Ahmed; Bertrand Friguet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-17
Journal Detail:
Title:  Oxidative medicine and cellular longevity     Volume:  2012     ISSN:  1942-0994     ISO Abbreviation:  Oxid Med Cell Longev     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-05     Completed Date:  2013-04-03     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101479826     Medline TA:  Oxid Med Cell Longev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  919832     Citation Subset:  IM    
Laboratoire de Biologie Cellulaire du Vieillissement, UR4-IFR83, Université Pierre et Marie Curie-Paris 6, 4 Place Jussieu, 75252 Paris Cedex 05, France.
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MeSH Terms
Aging / metabolism,  pathology*
Cell Aging*
Computational Biology
Fibroblasts / metabolism,  pathology
Oxidative Stress*
Protein Carbonylation
Proteins / metabolism*
Signal Transduction
Reg. No./Substance:

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