Document Detail

Protein nutrition and amino acid metabolism after 4 weeks of total parenteral nutrition with a mixture of 14 dipeptides: serendipitous observations on effects of sepsis in baboons.
MedLine Citation:
PMID:  3088969     Owner:  NLM     Status:  MEDLINE    
We investigated parameters of nutrition, metabolism, and organ function after 4 wk of total parenteral nutrition (TPN) in baboons receiving either dipeptides or amino acids as the nitrogen source. The two groups showed no significant difference with respect to gain in body weight, nitrogen balance, plasma and muscle concentrations of amino acids, plasma concentrations of proteins, and leucine incorporation into muscle protein. All dipeptides were efficiently utilized as evidenced by trace concentrations of dipeptides in plasma and urine; they produced no deleterious effect on the function of liver, kidney, or immune system. Development of infection in several baboons increased urinary excretion of urea nitrogen but had no effect on urinary excretion of dipeptides and amino acids with the single exception of taurine, which was greatly increased. In conclusion, the data show long-term efficacy and safety of the dipeptide mixture as the sole nitrogen source for TPN.
J A Vazquez; G A Paleos; H J Steinhardt; K Langer; M Brandl; W L Fekl; S A Adibi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  44     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-08-08     Completed Date:  1986-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  24-32     Citation Subset:  AIM; IM    
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MeSH Terms
Amino Acids / administration & dosage,  metabolism*
Blood Proteins / metabolism
Blood Urea Nitrogen
Body Weight
Dietary Proteins / metabolism
Dipeptides / administration & dosage*
Food, Formulated*
Infection / metabolism*
Muscle Proteins / metabolism
Nitrogen / metabolism
Parenteral Nutrition, Total*
Proteins / metabolism*
Time Factors
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Blood Proteins; 0/Dietary Proteins; 0/Dipeptides; 0/Muscle Proteins; 0/Proteins; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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