Document Detail

Protein nitration, lipid peroxidation and DNA damage at high altitude in acclimatized lowlanders and native highlanders: relation with oxygen consumption.
MedLine Citation:
PMID:  20215049     Owner:  NLM     Status:  MEDLINE    
Reactive oxygen and nitrogen species have been reported to be increased due to hypobaric hypoxia. It was hypothesized that lowlanders are more susceptible to protein nitration, lipid peroxidation and DNA damage at high altitude than highlanders and formation of these biomarkers may have strong correlation with oxygen consumption. Male volunteers were randomly selected and categorized into 3 groups, i.e. lowlanders at sea level (LL-SL, n=10), lowlanders at an altitude of 4560 m (LL-HA, n=10) and highlanders (HAN, n=10). Volunteers performed maximal aerobic exercise. Resting and post-exercise blood samples were taken at sea level and high altitude. Both resting and maximum oxygen consumption showed positive correlation with stress markers. LL-HA showed increased 3-nitrotyrosine and lipid hydroperoxide than LL-SL at rest. 3-Nitrotyrosine and lipid hydroperoxide increased after exercise in 3 groups, but percentage increase was higher in HAN than LL-SL and LL-HA. LL-SL and HAN showed significant DNA damage after exercise. Results indicate that resting oxygen consumption is positively correlated with nitrosative and oxidative stress markers irrespective of environmental condition and adaptation levels. Lowlanders have shown higher susceptibility to hypoxic insult than highlanders at rest, but when subjected to exercise test, they showed better tolerance to hypoxia than highlanders.
Sanchari Sinha; Arkadeb Dutta; Som Nath Singh; Uday Sankar Ray
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-06
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  171     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  115-21     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier B.V. All rights reserved.
Environmental Physiology Division, Defence Institute of Physiology and Allied Sciences, Timarpur, Lucknow Road, Delhi 110054, India.
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MeSH Terms
Acclimatization / physiology*
Biological Markers / blood
DNA Damage / physiology*
Exercise / physiology
Lipid Peroxidation / physiology*
Oxidative Stress / physiology*
Oxygen / blood
Oxygen Consumption / physiology*
Random Allocation
Rest / physiology
Tyrosine / analogs & derivatives*,  blood
Reg. No./Substance:
0/Biological Markers; 3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine; 7782-44-7/Oxygen

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