Document Detail

Protein metabolism in pregnancy.
MedLine Citation:
PMID:  10799398     Owner:  NLM     Status:  MEDLINE    
Adaptation to pregnancy involves major changes in maternal metabolism to provide for the growing demands of the conceptus. Although changes in glucose metabolism, and possibly in fatty acid metabolism, occur in parallel with the increasing energy demands of the mother and the fetus, adaptation of protein metabolism appears to be in anticipation of maternal and fetal needs. During pregnancy, there is an excess of maternal nitrogen in the form of lean body mass over that deposited in the fetus and the products of conception; there is also a pregnancy-induced hypoaminoacidemia and a diminished amino acid response to protein intake, suggesting an increased uptake of amino acids in the splanchnic compartment. With the use of stable-isotope-labeled tracers, it was shown that there is a decreased rate of urea synthesis during pregnancy that is evident early in gestation. Kinetic studies of leucine metabolism showed no significant change in leucine carbon turnover but a significantly lower rate of leucine nitrogen turnover, suggesting a lower rate of leucine transamination. These data suggest an integral regulation of whole-body protein and nitrogen metabolism starting early in gestation and aimed at conservation and accretion of nitrogen by the mother and the fetus.
S C Kalhan
Related Documents :
24525628 - Patterns of opioid utilization in pregnancy in a large cohort of commercial insurance b...
9512318 - Serum levels of human placental lactogen, pregnancy-associated plasma protein a and end...
10772198 - Characteristics of normal lochia.
19003638 - Advanced glycation end products in pregnancies complicated with diabetes mellitus or pr...
24374868 - Ascites, anemia and (intestinal) atresia.
11470378 - Repeated prenatal corticosteroid administration delays astrocyte and capillary tight ju...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  71     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-25     Completed Date:  2000-05-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1249S-55S     Citation Subset:  AIM; IM    
Robert Schwartz MD Center for Metabolism and Nutrition and the Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109-1998, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptation, Physiological*
Dietary Proteins / metabolism*
Leucine / metabolism
Pregnancy / metabolism*
Urea / metabolism
Grant Support
Reg. No./Substance:
0/Dietary Proteins; 57-13-6/Urea; 61-90-5/Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Obesity and pregnancy: complications and cost.
Next Document:  Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus.