Document Detail


Protein metabolism in pregnancy.
MedLine Citation:
PMID:  10799398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adaptation to pregnancy involves major changes in maternal metabolism to provide for the growing demands of the conceptus. Although changes in glucose metabolism, and possibly in fatty acid metabolism, occur in parallel with the increasing energy demands of the mother and the fetus, adaptation of protein metabolism appears to be in anticipation of maternal and fetal needs. During pregnancy, there is an excess of maternal nitrogen in the form of lean body mass over that deposited in the fetus and the products of conception; there is also a pregnancy-induced hypoaminoacidemia and a diminished amino acid response to protein intake, suggesting an increased uptake of amino acids in the splanchnic compartment. With the use of stable-isotope-labeled tracers, it was shown that there is a decreased rate of urea synthesis during pregnancy that is evident early in gestation. Kinetic studies of leucine metabolism showed no significant change in leucine carbon turnover but a significantly lower rate of leucine nitrogen turnover, suggesting a lower rate of leucine transamination. These data suggest an integral regulation of whole-body protein and nitrogen metabolism starting early in gestation and aimed at conservation and accretion of nitrogen by the mother and the fetus.
Authors:
S C Kalhan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  71     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-25     Completed Date:  2000-05-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1249S-55S     Citation Subset:  AIM; IM    
Affiliation:
Robert Schwartz MD Center for Metabolism and Nutrition and the Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109-1998, USA. sck@po.cwru.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Dietary Proteins / metabolism*
Female
Humans
Leucine / metabolism
Pregnancy / metabolism*
Urea / metabolism
Grant Support
ID/Acronym/Agency:
HD11089/HD/NICHD NIH HHS; RR00080/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Proteins; 57-13-6/Urea; 61-90-5/Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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