Document Detail

Protein metabolism in the extremely low-birth weight infant.
MedLine Citation:
PMID:  10690563     Owner:  NLM     Status:  MEDLINE    
Although extensive data are available on the impact of nutrient and protein administration on growth, plasma amino acids, and nitrogen balance in the newborn and growing infants, relatively few studies have carefully examined the dynamic aspects of protein metabolism in vivo and particularly in the micropremie or ELBW infant. These studies show that the very preterm infants, either because of immaturity or because of the intercurrent illness, have high rates of protein turnover and protein breakdown. This high rate of proteolysis is not as responsive to nutrient administration. Intervention strategies aimed at promoting nitrogen accretion, such as insulin, human growth hormone, or glutamine, have not thus far resulted in enhanced protein accretion and growth. This may be, in part, due to limitations in delivery of adequate calorie and nitrogen.
S C Kalhan; S Iben
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  27     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-16     Completed Date:  2000-03-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  23-56     Citation Subset:  IM    
Robert Schwartz, MD, Center for Metabolism & Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
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MeSH Terms
Energy Metabolism
Enteral Nutrition
Growth Hormone / therapeutic use
Infant, Newborn
Infant, Premature / metabolism*
Infant, Very Low Birth Weight / metabolism*
Insulin / therapeutic use
Nitrogen / metabolism
Proteins / metabolism*
Urea / metabolism
Grant Support
Reg. No./Substance:
0/Proteins; 11061-68-0/Insulin; 57-13-6/Urea; 7727-37-9/Nitrogen; 9002-72-6/Growth Hormone

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