Document Detail

Protein-losing gastropathy associated with autoimmune disease: successful treatment with prednisolone.
MedLine Citation:
PMID:  11931534     Owner:  NLM     Status:  MEDLINE    
We report a patient with protein-losing gastropathy probably associated with autoimmune disease, in whom prednisolone treatment was highly effective. A 45-year-old woman was admitted to our hospital with edema of the face and lower extremities. Blood examination revealed hypoproteinemia, hypoalbuminemia, and hypercholesteremia. Renal biopsy revealed no definite findings of lupus nephritis, including vasculitis. A diagnosis of protein-losing gastropathy was made on the basis of increased alpha1-antitrypsin clearance and 99mTc-labeled human serum albumin scintigram showing abnormal radioactivity in the stomach. Endoscopic gastric biopsies revealed nonspecific inflammation, but marked intramural edema. Based on a slight elevation of antinuclear antibody level, autoimmune disease was suspected to be involved in this patient. Administration of prednisolone, as a diagnostic therapy, alleviated the hypoproteinemia, hypoalbuminemia, and hypercholesteremia. These findings suggest that an autoimmune mechanism could have been involved in this case of protein-losing gastropathy.
Toshihiro Aoki; Noriyuki Noma; Ichiro Takajo; Jun-Ichi Yamaga; Masaaki Otsuka; Hiroaki Yuchi; Naoto Ishikawa; Haruhiko Inatsu; Jun-Ichiro Sakata; Yushiro Asada; Tanenao Eto
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  37     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2002  
Date Detail:
Created Date:  2002-04-04     Completed Date:  2002-10-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
First Department of Internal Medicine. Department of Pathology, Miyazaki Medical College, Kiyotake, Japan.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Antibodies, Antinuclear / analysis
Autoimmune Diseases / complications,  diagnosis
Edema / drug therapy,  etiology
Hypoproteinemia / etiology
Lupus Erythematosus, Systemic / complications,  diagnosis,  drug therapy*
Middle Aged
Prednisolone / therapeutic use*
Protein-Losing Enteropathies / complications,  diagnosis,  drug therapy*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Antinuclear; 50-24-8/Prednisolone

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