| Protein localization during the Caulobacter crescentus cell cycle. | |
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MedLine Citation:
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PMID: 10066543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New research on bacterial cells has demonstrated that they have a dynamic and complex subcellular organization. Work in Caulobacter crescentus shows that essential and nonessential proteins localize to discrete positions in the cell as a function of cell-cycle progression. The flagellum and chemotaxis receptor are asymmetrically localized to a single pole in the predivisional cell by coordinated proteolysis and transcriptional regulation. Cell type- and compartment-specific localization of the CtrA global transcriptional regulator is essential for proper cell-cycle progression, and subcellular localization of key chromosome partitioning proteins is correlated with proper nucleoid segregation. Given this structural complexity, we are driven to ask how localization is achieved, and to what end. |
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Authors:
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R T Wheeler; J W Gober; L Shapiro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current opinion in microbiology Volume: 1 ISSN: 1369-5274 ISO Abbreviation: Curr. Opin. Microbiol. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-08-06 Completed Date: 1999-08-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9815056 Medline TA: Curr Opin Microbiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 636-42 Citation Subset: IM |
Affiliation:
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Department of Developmental Biology, Beckman Center for Molecular and Genetic Medicine, Stanford University, Stanford, CA 94305-5427, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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genetics*,
metabolism* Caulobacter crescentus / genetics, growth & development*, metabolism* Cell Cycle Flagella / metabolism Gene Expression Regulation, Bacterial |
| Grant Support | |
ID/Acronym/Agency:
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GM 32506/5120MZ/GM/NIGMS NIH HHS; GM 51426/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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