Document Detail

Protein kinase C affects reformation of endothelial junctions in xenopus XTH-2 cells.
MedLine Citation:
PMID:  10527549     Owner:  NLM     Status:  MEDLINE    
Endothelial cells can reversibly be forced to suppress the formation of endothelial junctions (EJ) by cultivation in a low calcium medium. The authors localized vinculin and cadherin as marker proteins of EJ and actin as a cytoskeletal component by fluorescence microscopy, and used this cell model to study the reformation of endothelial junctions under conditions of activation and inhibition of protein kinase C (PKC). Inhibition of PKC by H-7 leads to an acceleration of EJ reformation, while constitutive activation by TPA inhibits the reformation process.
N S Werner; R Meyer; F Achenbach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biology international     Volume:  23     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  1999  
Date Detail:
Created Date:  2000-04-04     Completed Date:  2000-04-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Innere Klinik und Poliklinik (Tumorforschung), Universitätsklinikum Essen, Hufelandstr. 55, Essen, D-45122, Germany.
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MeSH Terms
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / pharmacology
Cadherins / physiology
Cell Line
Endothelium, Vascular / cytology*,  physiology*
Enzyme Activation / physiology
Enzyme Inhibitors / pharmacology
Intercellular Junctions / physiology*
Phorbol Esters / pharmacology
Protein Kinase C / physiology*
Signal Transduction
Vinculin / physiology
Reg. No./Substance:
0/Cadherins; 0/Enzyme Inhibitors; 0/Phorbol Esters; 125361-02-6/Vinculin; 84477-87-2/1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; EC Kinase C

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