| Protein kinase C activity is not responsible for the expression of long-term potentiation in hippocampus. | |
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MedLine Citation:
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PMID: 2161529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long-term potentiation (LTP) in hippocampus has been proposed to result from a tonic activation of protein kinase C. This hypothesis predicts that stimulation of the kinase would produce a smaller change in response size on potentiated versus control pathways and, conversely, that inhibition of the kinase would reduce potentiated inputs to a greater degree than control responses. We tested these predictions using phorbol esters to activate and using the antagonist H-7 to inhibit protein kinase C; we found that the actions of these drugs on synaptic transmission were not affected by prior induction of LTP. Both compounds, however, significantly decreased the contribution of N-methyl-D-aspartate receptors to synaptic potentials, a result that accounts for the suppressive effects of these compounds on LTP formation. Thus protein kinase C is probably not involved in the expression of LTP but may play a role in the receptor-mediated events participating in its induction. |
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Authors:
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D Muller; P A Buchs; Y Dunant; G Lynch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 87 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-07-12 Completed Date: 1990-07-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4073-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Centre Medical Universitaire, Geneva, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Animals Hippocampus / enzymology* Isoquinolines / pharmacology Membrane Potentials / drug effects Neuronal Plasticity / physiology* Phorbol Esters / pharmacology Piperazines / pharmacology Protein Kinase C / antagonists & inhibitors, physiology* Rats Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter / physiology Synaptic Transmission / drug effects, physiology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Isoquinolines; 0/Phorbol Esters; 0/Piperazines; 0/Receptors, N-Methyl-D-Aspartate; 0/Receptors, Neurotransmitter; 84477-87-2/1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; EC 2.7.11.13/Protein Kinase C |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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