| Protein interactions at the heart of cardiac chamber formation. | |
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MedLine Citation:
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PMID: 19647421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The vertebrate heart is a muscular pump that contracts in a rhythmic fashion to propel the blood through the body. During evolution, the morphologically complex four-chambered heart of birds and mammals has evolved from a single-layered tube with peristaltic contractility. The heart of Drosophila, referred to as the dorsal vessel, is a blind sac composed of myogenic cells that contract rhythmically. The fish heart is composed of a single atrial chamber connected to a single ventricular chamber. The evolutionary development of fast-contracting chambers allowed the heart to build up high blood pressures. In amphibians two atrial chambers exist, separated by a septum, connecting to a single ventricle. The division of a common atrium and ventricle into right and left-sided chambers represents an evolutionary milestone in the development of the four-chambered heart and is necessary for separation of oxygenated and deoxygenated blood. In amphibians and reptiles, pulmonary and systemic circulations are incompletely separated allowing adaptable blood flows to both circulations. In contrast, the hearts of birds and mammals, in which septa completely separate the pulmonary and systemic circulations, both circulations have similar flows, but blood pressures can be regulated separately. In this review we focus, in a morphologically integrated fashion, on the molecular interactions that govern the intricate cardiac design. |
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Authors:
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Cornelis J J Boogerd; Antoon F M Moorman; Phil Barnett |
Publication Detail:
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Type: Journal Article; Review Date: 2009-07-02 |
Journal Detail:
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Title: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft Volume: 191 ISSN: 1618-0402 ISO Abbreviation: Ann. Anat. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2010-02-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100963897 Medline TA: Ann Anat Country: Germany |
Other Details:
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Languages: eng Pagination: 505-17 Citation Subset: IM |
Copyright Information:
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2009 Elsevier GmbH. |
Affiliation:
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Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Cell Cycle Proteins / physiology Cell Differentiation Embryonic Development Heart / anatomy & histology*, embryology, physiology Heart Conduction System / physiology Humans Mesoderm / physiology Mice Myocardium / metabolism* Proteins / metabolism* T-Box Domain Proteins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Proteins; 0/T-Box Domain Protein 2; 0/T-Box Domain Proteins; 0/TBX3 protein, human; 0/Tbx3 protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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