Document Detail

Protein intake in the first year of life: a risk factor for later obesity? The E.U. childhood obesity project.
MedLine Citation:
PMID:  16137110     Owner:  NLM     Status:  MEDLINE    
Effective strategies for primary prevention are urgently needed to combat the rapidly increasing prevalence of childhood obesity. Evidence accumulates that early nutrition programmes later obesity risk. Breast feeding reduces the odds ratio for obesity at school age, adjusted for biological and sociodemographic confounding variables, by some 20-25%. We propose that the protective effect of breast feeding is related in part by the induction of a lower weight gain in infancy, which is related to differences in substrate intake. Protein intake per kg bodyweight is some 55-80% higher in formula fed than in breast fed infants. We hypothesize that high early protein intakes in excess of metabolic requirements enhance weight gain in infancy and increase later obesity risk (the "early protein hypothesis"). The European Childhood Obesity Programme tests this hypothesis in a randomized double blind intervention trial in 1150 infants in five European centres. Infants that are not breast fed are randomized to formulae with higher or lower protein content and followed up to school age. If an effect of infant feeding habits on later obesity risk should be established, there is great potential for effective preventive intervention with a significant potential health benefit for the child and adult population.
Berthold Koletzko; Ilse Broekaert; Hans Demmelmair; Jeanette Franke; Iris Hannibal; Doris Oberle; Sonja Schiess; Blanca Troy Baumann; Sabine Verwied-Jorky;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  569     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-02     Completed Date:  2005-12-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-79     Citation Subset:  IM    
Divison of Metabolic Diseases and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich, Lindwurmstr. 4, D-80337 München, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Child, Preschool
Dietary Proteins / administration & dosage*,  adverse effects*
Infant Food
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Obesity / epidemiology*,  prevention & control
Randomized Controlled Trials as Topic
Risk Factors
Substrate Specificity / physiology
Reg. No./Substance:
0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Best practice in communicating the results of European research to the public.
Next Document:  The role of long-chain polyunsaturated fatty acids (LCPUFA) in growth and development.