Document Detail


Protein image alignment via piecewise affine transformations.
MedLine Citation:
PMID:  16706715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a new approach for aligning families of 2D gels. Instead of choosing one of the gels as reference and performing a pairwise alignment, we construct an ideal gel that is representative of the entire family and obtain a set of piecewise affine transformations that optimally align each gel of the family to the ideal gel. The coefficients defining the transformations as well as the ideal landmarks are obtained as the solution of a large-scale quadratic programming problem that can be solved efficiently by interior-point methods.
Authors:
Florian A Potra; Xing Liu; Françoise Seillier-Moiseiwitsch; Anindya Roy; Yaming Hang; Mark R Marten; Babu Raman; Carol Whisnant
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of computational biology : a journal of computational molecular cell biology     Volume:  13     ISSN:  1066-5277     ISO Abbreviation:  J. Comput. Biol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-18     Completed Date:  2006-07-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9433358     Medline TA:  J Comput Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-30     Citation Subset:  IM    
Affiliation:
Department of Mathematics and Statistics, University of Maryland, Baltimore, MD 21250, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Electrophoresis, Gel, Two-Dimensional
Humans
Image Processing, Computer-Assisted*
Proteome / analysis*
Proteomics*
Grant Support
ID/Acronym/Agency:
R01 GM075298/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Proteome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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