| Protein expression and intracellular localization of prostate apoptosis response-4 (Par-4) are associated with apoptosis induction in nasopharyngeal carcinoma cell lines. | |
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MedLine Citation:
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PMID: 17881119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostate apoptosis response-4 (Par-4) is a proapoptotic gene that selectively induces cell death in most cancer cells. In addition to the increased percentage of apoptotic cells, caspase-3 activity, and poly (ADP-ribose) polymerase (PARP) cleavage, we demonstrate that elevated expression of Par-4 and nuclear entry resulted in apoptosis of nasopharyngeal carcinoma (NPC) cell lines either in serum deprivation or by ectopic overexpression of Par-4. Moreover, disassociation from the Par-4/Akt complex was correlated with the induced proapoptotic ability of Par-4. Therefore, our data suggest that the cytoplasmic localization and expression level of endogenous Par-4 in NPC cells are not sufficient to augment apoptosis. |
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Authors:
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Jeng-Woei Lee; Kuei-Fang Lee; Hsue-Yin Hsu; Lee-Ping Hsu; Wen-Ling Shih; Yi-Chih Chu; Wei-Ting Hsiao; Po-Fan Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-18 |
Journal Detail:
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Title: Cancer letters Volume: 257 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-15 Completed Date: 2008-01-03 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 252-62 Citation Subset: IM |
Affiliation:
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Department and Institute of Life Science, College of Life Science, Tzu-Chi University, 701, Sec. 3, Chung-Yang Road, Hualien 97071, Taiwan. jwlee@mail.tcu.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
/
drug effects,
genetics,
physiology* Apoptosis Regulatory Proteins / genetics, metabolism* Blotting, Western Caspase 3 / metabolism Cell Line, Tumor Cell Nucleus / metabolism Cell Survival / drug effects, genetics, physiology Culture Media, Serum-Free / pharmacology Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic / drug effects Humans Intracellular Fluid / drug effects, metabolism* Nasopharyngeal Neoplasms / genetics, metabolism, pathology Poly(ADP-ribose) Polymerases / metabolism Protein Binding Proto-Oncogene Proteins c-akt / metabolism Proto-Oncogene Proteins c-bcl-2 / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction Time Factors Transfection |
| Chemical | |
Reg. No./Substance:
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0/Apoptosis Regulatory Proteins; 0/Culture Media, Serum-Free; 0/Proto-Oncogene Proteins c-bcl-2; 0/prostate apoptosis response-4 protein; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 3.4.22.-/Caspase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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