| Protein-energy requirements in subjects with acute renal failure receiving intermittent hemodialysis. | |
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MedLine Citation:
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PMID: 6772006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Parenteral nutrition may reduce morbidity and mortality in acute renal failure. Ideally, negative protein (nitrogen) balance would be reversed. However, the intake of glucose and amino acids required to achieve positive balance have not been determined. We therefore examined the effects on protein balance of widely varying intakes of amino acids and hypertonic glucose in 14 acute renal failure patients receiving hemodialysis. Because plasma solute concentrations change continuously, a single compartment mathematical model was used to derive urea nitrogen losses from the urea nitrogen generation rate (Gun). During 32 study periods (averaging 6 days each), nutrient intake was maintained stable. Protein balance was then estimated from the amino acid nitrogen intake minus the Gun. On average. Gun (11.2 +/- 1.8 g/day) exceeded amino acid nitrogen intake (6.0 +/- 1.2 g/day) by 5.6 +/- 1.6 g/day, indicating negative protein balance. The high Gun is consistent with hypercatabolism in these subjects. Increased nutrient intake correlated significantly with improved protein balance for both the intake of glucose (r = 0.64) and amino acid nitrogen (r = 0.50). Nonetheless, protein balance became transiently positive in only four subjects, at which time the amino acid intake averaged 1.03 g/kg per day and glucose intake, 50 kcal/kg per day. We conclude that in hypercatabolic acute renal failure, protein and energy requirements considerably exceed those conventionally prescribed. |
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Authors:
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S C Spreiter; B D Myers; R S Swenson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 33 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1980 Jul |
Date Detail:
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Created Date: 1980-09-26 Completed Date: 1980-09-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1433-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dietary Proteins* Humans Kidney Failure, Acute / diet therapy*, therapy Middle Aged Parenteral Nutrition Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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