| Protein encapsulation within synthetic molecular hosts. | |
| | |
MedLine Citation:
|
PMID: 23033069 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Protein encapsulation has long attracted many chemists and biologists because of its potential to control the structure and functions of proteins, but has been a daunting challenge because of their incommensurably larger size compared with common synthetic hosts. Here we report the encapsulation of a small protein, ubiquitin, within giant coordination cages. The protein was attached to one bidentate ligand and, upon addition of Pd(II) ions (M) and additional ligands (L), M(12)L(24) coordination nanocages self-assembled around the protein. Because of the well-defined host framework, the protein-encapsulated structure could be analysed by NMR spectroscopy, ultracentrifugation and X-ray crystallography. |
| | |
Authors:
|
Daishi Fujita; Kosuke Suzuki; Sota Sato; Maho Yagi-Utsumi; Yoshiki Yamaguchi; Nobuhiro Mizuno; Takashi Kumasaka; Masaki Takata; Masanori Noda; Susumu Uchiyama; Koichi Kato; Makoto Fujita |
Related Documents
:
|
23471109 - Mass spectrometry of intact membrane protein complexes. 1091349 - Antipyretic effect of cycloheximide, and inhibitor of protein synthesis, in patients wi... 23490039 - Protein methylation at the surface and buried deep: thinking outside the histone box. 23583689 - Multiple interaction partners for cockayne syndrome proteins: implications for genome a... 23075429 - "fast photochemical oxidation of proteins" (fpop) and mass spectrometry follow sub-mill... 23353019 - The plasma membrane proteome of maize roots grown under low and high iron conditions. 7893719 - Is burst hydrophobic collapse necessary for protein folding? 15844489 - Applicability of the stoichiometric displacement model to description of the retention ... 8054659 - Development and partial characterization of monoclonal antibodies to venom of the paras... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nature communications Volume: 3 ISSN: 2041-1723 ISO Abbreviation: Nat Commun Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101528555 Medline TA: Nat Commun Country: England |
Other Details:
|
Languages: eng Pagination: 1093 Citation Subset: IM |
Affiliation:
|
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
PubChem-Substance/144088983; 144088984; 144088985; 144088986; 144088987; 144088988; 144088989; 144088990; 144088991; 144088992; 144088993; 144088994; 144088995 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantum correlations with no causal order.
Next Document: Sound-induced length changes in outer hair cell stereocilia.