Document Detail

Protein encapsulation within synthetic molecular hosts.
MedLine Citation:
PMID:  23033069     Owner:  NLM     Status:  In-Data-Review    
Protein encapsulation has long attracted many chemists and biologists because of its potential to control the structure and functions of proteins, but has been a daunting challenge because of their incommensurably larger size compared with common synthetic hosts. Here we report the encapsulation of a small protein, ubiquitin, within giant coordination cages. The protein was attached to one bidentate ligand and, upon addition of Pd(II) ions (M) and additional ligands (L), M(12)L(24) coordination nanocages self-assembled around the protein. Because of the well-defined host framework, the protein-encapsulated structure could be analysed by NMR spectroscopy, ultracentrifugation and X-ray crystallography.
Daishi Fujita; Kosuke Suzuki; Sota Sato; Maho Yagi-Utsumi; Yoshiki Yamaguchi; Nobuhiro Mizuno; Takashi Kumasaka; Masaki Takata; Masanori Noda; Susumu Uchiyama; Koichi Kato; Makoto Fujita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature communications     Volume:  3     ISSN:  2041-1723     ISO Abbreviation:  Nat Commun     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528555     Medline TA:  Nat Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  1093     Citation Subset:  IM    
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Data Bank Information
Bank Name/Acc. No.:
PubChem-Substance/144088983;  144088984;  144088985;  144088986;  144088987;  144088988;  144088989;  144088990;  144088991;  144088992;  144088993;  144088994;  144088995
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