| Protein drug stability: a formulation challenge. | |
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MedLine Citation:
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PMID: 15803194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The increasing use of recombinantly expressed therapeutic proteins in the pharmaceutical industry has highlighted issues such as their stability during long-term storage and means of efficacious delivery that avoid adverse immunogenic side effects. Controlled chemical modifications, such as substitutions, acylation and PEGylation, have fulfilled some but not all of their promises, while hydrogels and lipid-based formulations could well be developed into generic delivery systems. Strategies to curb the aggregation and misfolding of proteins during storage are likely to benefit from the recent surge of interest in protein fibrillation. This might in turn lead to generally accepted guidelines and tests to avoid unforeseen adverse effects in drug delivery. |
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Authors:
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Sven Frokjaer; Daniel E Otzen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Drug discovery Volume: 4 ISSN: 1474-1776 ISO Abbreviation: Nat Rev Drug Discov Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-01 Completed Date: 2005-05-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101124171 Medline TA: Nat Rev Drug Discov Country: England |
Other Details:
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Languages: eng Pagination: 298-306 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen O, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drug Delivery Systems Drug Design* Drug Stability Humans Models, Molecular Recombinant Proteins* / administration & dosage, chemistry, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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