Document Detail


Protein drug stability: a formulation challenge.
MedLine Citation:
PMID:  15803194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increasing use of recombinantly expressed therapeutic proteins in the pharmaceutical industry has highlighted issues such as their stability during long-term storage and means of efficacious delivery that avoid adverse immunogenic side effects. Controlled chemical modifications, such as substitutions, acylation and PEGylation, have fulfilled some but not all of their promises, while hydrogels and lipid-based formulations could well be developed into generic delivery systems. Strategies to curb the aggregation and misfolding of proteins during storage are likely to benefit from the recent surge of interest in protein fibrillation. This might in turn lead to generally accepted guidelines and tests to avoid unforeseen adverse effects in drug delivery.
Authors:
Sven Frokjaer; Daniel E Otzen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature reviews. Drug discovery     Volume:  4     ISSN:  1474-1776     ISO Abbreviation:  Nat Rev Drug Discov     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-01     Completed Date:  2005-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101124171     Medline TA:  Nat Rev Drug Discov     Country:  England    
Other Details:
Languages:  eng     Pagination:  298-306     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen O, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Delivery Systems
Drug Design*
Drug Stability
Humans
Models, Molecular
Recombinant Proteins* / administration & dosage,  chemistry,  therapeutic use
Chemical
Reg. No./Substance:
0/Recombinant Proteins

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