Document Detail


Protein corona significantly reduces active targeting yield.
MedLine Citation:
PMID:  23423192     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.
Authors:
Vahid Mirshafiee; Morteza Mahmoudi; Kaiyan Lou; Jianjun Cheng; Mary L Kraft
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  49     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2013-08-28     Revised Date:  2014-03-31    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  2557-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Lipids / chemistry
Nanoparticles / chemistry*
Proteins / chemistry*
Silicon / chemistry
Surface Properties
Grant Support
ID/Acronym/Agency:
1R21CA152627/CA/NCI NIH HHS; R21 CA152627/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Lipids; 0/Proteins; Z4152N8IUI/Silicon
Comments/Corrections

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