Document Detail

Protein concentration and hydrostatic pressure in subcutaneous tissue of rats in hypoproteinemia.
MedLine Citation:
PMID:  1188299     Owner:  NLM     Status:  MEDLINE    
Protein concentration and hydrostatic pressure were measured in subcutaneous tissue of rats during development of aminonucleoside nephrosis. Samples of interstitial fluid for protein analysis were collected from subcutaneous tissue by a wick method, and hydrostatic pressure was measured by a modified Scholander technique. When the serum protein concentration was reduced from 6.1 to 4.8 g/100 ml, interstitial fluid protein concentration fell from 3.0 to 1.1 g/100 ml. This corresponds to a reduction of calculated oncotic pressures from 18.0 to 13.0 mm Hg and from 7.8 to 3.0 mm Hg in serum and interstitial fluid, respectively, thus leaving a nearly constant net transcapillary oncotic pressure. When serum protein concentration was further reduced to 3.8 g/100 ml, interstitial fluid protein concentration was reduced to 0.5 g/100 ml, reducing net transcapillary oncotic pressure by 2-3 mm Hg. The average hydrostatic pressure in subcutis was 1.0 mm Hg subatmospheric under control conditions and did not change during hypoproteinemia. The results indicate that a reduction of interstitial protein concentration is an important factor in preventing edema formation in hypoproteinemia.
H O Fadnes
Related Documents :
879329 - Determinants of isogravimetric capillary pressure in the isolated dog hindlimb.
18761499 - The mechanisms of refilling of xylem conduits and bleeding of tall birch during spring.
826179 - Dependence of cr-edta absorption from the rumen on luminal osmotic pressure.
2621639 - Ultrastructure of transport pathways in stressed synovium of the knee in anaesthetized ...
7192099 - The effect of osmotic pressure on the intestinal absorption of sulfafurazol and ethanol...
17096869 - Can passive leg raising be used to guide fluid administration?
15672969 - Early diagnosis of trophoblast produced capillary hypertension (pregnancy-induced hyper...
898239 - Cardiac arrhythmias in experimental subarachnoid hemorrhage.
12467799 - Haptic reproduction and interactive visualization of a beating heart for cardiovascular...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  35     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-01-29     Completed Date:  1976-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Proteins / analysis
Capillary Permeability
Extracellular Space / analysis*
Hydrostatic Pressure*
Hypoproteinemia / blood,  metabolism,  physiopathology*
Osmotic Pressure
Proteins / analysis*
Skin / analysis*
Reg. No./Substance:
0/Blood Proteins; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bone mineral content and estimated total body calcium in normal adults.
Next Document:  Ultrasonic measurement of sound velocity in whole blood. A comparison between an ultrasonic method a...