Document Detail


Protein concentration and hydrostatic pressure in subcutaneous tissue of rats in hypoproteinemia.
MedLine Citation:
PMID:  1188299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protein concentration and hydrostatic pressure were measured in subcutaneous tissue of rats during development of aminonucleoside nephrosis. Samples of interstitial fluid for protein analysis were collected from subcutaneous tissue by a wick method, and hydrostatic pressure was measured by a modified Scholander technique. When the serum protein concentration was reduced from 6.1 to 4.8 g/100 ml, interstitial fluid protein concentration fell from 3.0 to 1.1 g/100 ml. This corresponds to a reduction of calculated oncotic pressures from 18.0 to 13.0 mm Hg and from 7.8 to 3.0 mm Hg in serum and interstitial fluid, respectively, thus leaving a nearly constant net transcapillary oncotic pressure. When serum protein concentration was further reduced to 3.8 g/100 ml, interstitial fluid protein concentration was reduced to 0.5 g/100 ml, reducing net transcapillary oncotic pressure by 2-3 mm Hg. The average hydrostatic pressure in subcutis was 1.0 mm Hg subatmospheric under control conditions and did not change during hypoproteinemia. The results indicate that a reduction of interstitial protein concentration is an important factor in preventing edema formation in hypoproteinemia.
Authors:
H O Fadnes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  35     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-01-29     Completed Date:  1976-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Proteins / analysis
Capillary Permeability
Extracellular Space / analysis*
Female
Hydrostatic Pressure*
Hypoproteinemia / blood,  metabolism,  physiopathology*
Male
Osmotic Pressure
Pressure*
Proteins / analysis*
Rats
Skin / analysis*
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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