Document Detail

Protein-calorie malnutrition in liver cirrhosis.
MedLine Citation:
PMID:  1392415     Owner:  NLM     Status:  MEDLINE    
The purpose of this article is to present detailed data on the nutritional assessment in cirrhotic patients. The exact frequency and types of malnutrition, its associations with the aetiology of liver disease, liver dysfunction and clinical staging in liver cirrhosis are unknown. A new classification system is presented which may help to suggest some interventional guidelines. Physical (anthropometry, 24-h urinary creatinine excretion, bioelectrical impedance analysis (BIA), total body potassium counting, ultrasound examination) and metabolic (indirect calorimetry) assessment of nutritional status was therefore performed in 123 patients with liver cirrhosis, who were considered as potential candidates for liver transplantation. Data were related to the clinical, biochemical, histological and prognostic data of liver disease. Of our patients 65% showed some signs of protein-calorie malnutrition as indicated by low body cell mass, reduced serum albumin concentrations or abnormal skinfold thickness. Of these 34% were considered as "kwashiorkor-like" (normal body composition, serum albumin less than 35 g/l), and 18% were "marastic" (reduced body weight, body cell mass, and fat mass). However, 49% of the malnourished group had reduced body cell mass in association with increased fat mass and frequently presented with a normal body weight ("mixed" or "obese" type). Protein-calorie malnutrition did not correlate with the aetiology of the disease and biochemical parameters of liver function. Malnutrition was observed at all clinical stages but was more frequently seen at advanced stages. We conclude that malnutrition associated with liver cirrhosis is not a clear phenomenon. Its clinical presentation is heterogenous and not reflected by the histological or biochemical parameters of liver disease.(ABSTRACT TRUNCATED AT 250 WORDS)
H U Lautz; O Selberg; J Körber; M Bürger; M J Müller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Clinical investigator     Volume:  70     ISSN:  0941-0198     ISO Abbreviation:  Clin Investig     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-11-02     Completed Date:  1992-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9207154     Medline TA:  Clin Investig     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  478-86     Citation Subset:  IM    
Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover.
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MeSH Terms
Energy Metabolism
Liver Cirrhosis / complications*,  etiology,  physiopathology
Liver Function Tests
Middle Aged
Nutrition Assessment
Protein-Energy Malnutrition / etiology*,  physiopathology

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