Document Detail

Protein and antioxidants in an isocaloric carbohydrate drink: effect on plasma oxidative-stress markers and IL-6.
MedLine Citation:
PMID:  19478337     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine whether an isocaloric beverage with added protein and vitamins (CHOPA) would influence oxidative stress and inflammation after cycling to exhaustion as indicated by plasma protein carbonyls (PC), lipid hydroperoxides (LOOH), and interleukin-6 (IL-6). Twelve trained men (18-33 yr) volunteered and performed this randomized crossover study. Participants cycled at 70% VO2peak until fatigue and at 80% VO2peak 22-24 hr later to fatigue with either carbohydrate or CHOPA. Blood collected before the cycling at rest and 24, 48, and 72 hr after the exercise was analyzed for PC and LOOH spectrophotometrically and for IL-6 via an enzyme-linked immunosorbent assay. The data were analyzed with SPSS using repeated-measures ANOVA. PC demonstrated significant treatment (p = .037) and time (p = .004) effects with no Treatment x Time interaction. PC was higher in the CHOPA treatment than with CHO independent of time and increased at 24 (48%), 48 (59%), and 72 (67%) hr after exercise compared with preexercise values. Resting LOOH and IL-6 did not have any significant changes with time or treatment. These data indicate that an isocaloric CHOPA drink after 2 cycling bouts to exhaustion will exacerbate the resting PC level compared with an isocaloric drink, with no influence on plasma LOOH or IL-6. In addition, a modest significant increase in PC over time independent of treatment occurred, which suggests a mild oxidative stress in the days after exhaustive exercise.
Alan H Goldfarb; Changmo Cho; Hojune Cho; Brett Romano-Ely; M Kent Todd
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  19     ISSN:  1526-484X     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-26     Citation Subset:  IM    
Department of Exercise and Sport Science, University of North Carolina, Greensboro, NC, USA.
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MeSH Terms
Analysis of Variance
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology
Bicycling / physiology
Cross-Over Studies
Dietary Carbohydrates / administration & dosage
Dietary Proteins / pharmacology*
Exercise / physiology*
Interleukin-6 / blood*
Lipid Peroxides / blood
Oxidative Stress / drug effects*
Protein Carbonylation / drug effects
Vitamin E / pharmacology
Vitamins / pharmacology*
Young Adult
Reg. No./Substance:
0/Antioxidants; 0/Dietary Carbohydrates; 0/Dietary Proteins; 0/Interleukin-6; 0/Lipid Peroxides; 0/Vitamins; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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