Document Detail

Protein aggregation reactions: surface free energy model.
MedLine Citation:
PMID:  7967625     Owner:  NLM     Status:  MEDLINE    
The energetics of protein reactions can be evaluated in terms of the surface free-energy model, an approach that estimates changes in the surface free energy of proteins from changes in the area and the charge density of the protein-water interface. This approach has given insight into the reactions of proteins in solution as well as in membranes (receptors and voltage-gated channels). The model highlights the importance of pH and thermal changes in aggregation reactions. It also enables a correct interpretation of the Hill equation describing co-operative reactions, since the Hill coefficient is related to a Gibbs surface excess that varies with the degree of reaction.
M Blank
Related Documents :
22814405 - Differences in the glycosylation of recombinant proteins expressed in hek and cho cells.
19384995 - Identifying native-like protein structures with scoring functions based on all-atom ece...
18579775 - Multiphoton fabrication of chemically responsive protein hydrogels for microactuation.
18424505 - Cavity-creating mutations in pseudomonas aeruginosa azurin: effects on protein dynamics...
25131595 - Prion disease and the 'protein-only hypothesis'.
16604415 - A proteomic approach towards the analysis of salt tolerance in rhizobium etli and sinor...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of theoretical biology     Volume:  169     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-12-16     Completed Date:  1994-12-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  IM    
Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians & Surgeons, New York, NY 10032.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chemistry, Physical
Hydrogen-Ion Concentration
Models, Chemical*
Physicochemical Phenomena
Proteins / chemistry*
Water / chemistry
Reg. No./Substance:
0/Proteins; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Do alcohol and lead change the sex ratio?
Next Document:  Dormancy, regression, and recurrence: towards a unifying theory of tumor growth control.