| Protein Z in patients with pregnancy complications. | |
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MedLine Citation:
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PMID: 16260213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was undertaken to evaluate the association between protein Z concentration and pregnancy complications. STUDY DESIGN: A prospective case-control study was conducted over a 2-year period to evaluate the prevalence of protein Z deficiency in pregnancy complications. Protein Z levels were measured at the time of diagnosis of complications such as preeclampsia, intrauterine growth restriction, and intrauterine fetal demise. Protein Z deficiency was defined as a plasma level below 1.2 mg/L. In addition to patients presenting with pregnancy complications, healthy age-matched nonpregnant and pregnant women were invited to participate. RESULTS: A total of 145 women were included in the study: 50 nonpregnant women, 34 healthy pregnant women, 29 women with preeclampsia, 25 women presented with intrauterine growth restriction, and 7 women with intrauterine fetal demise. The median protein Z level was similar in healthy pregnant and nonpregnant women (1.63 [0.47-3.1] mg/L and 1.69 [0.7-3] mg/L, respectively). Three women with normal pregnancies had a low protein Z level (8.8%), compared with 8 patients presenting with intrauterine growth restriction (33.3%) and 8 patients with intrauterine fetal demise (50%). Compared with normal pregnancy, the frequency of decreased protein Z was significantly higher in cases of intrauterine growth restriction and in intrauterine fetal demise (relative risk [RR] 1.96, 95% CI 1.16-3.32; P = .041 and RR 3.36, 95% CI 1.65-6.8; P = .0031, respectively), but not in preeclampsia (RR 1.6, 95% CI 0.9-2.8; P = .23). Placenta histologic examination revealed vascular lesions in 50% of patients with protein Z deficiency and in 33% of patients with normal levels of protein Z (RR 0.84; 95% CI 0.6-1.2). CONCLUSION: Protein Z deficiency is associated with late fetal demise and intrauterine growth restriction. The pathophysiologic role of protein Z deficiency, either congenital or caused by the presence of specific antibodies remains unclear and should be further investigated. |
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Authors:
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Florence Bretelle; Dominique Arnoux; Raha Shojai; Claude D'Ercole; José Sampol; Françoise Dignat; Laurence Camoin-Jau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 193 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-01 Completed Date: 2006-01-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1698-702 Citation Subset: AIM; IM |
Affiliation:
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Service de Gynécologie-Obstétrique, Pr. B. Blanc, Centre Hospitalo-Universitaire de la Conception, 13385 Marseille Cedex, France. florence.bretelle@mail.ap-hm.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Proteins / deficiency* Case-Control Studies Female Humans Pregnancy Pregnancy Complications / epidemiology* Prevalence Prospective Studies Protein Deficiency / complications, epidemiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/plasma protein Z |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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