| Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation. | |
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MedLine Citation:
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PMID: 23154872 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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By specifically labeling leucine/valine methyl groups and lysine side chains "inside" and "outside" dynamics of proteins on the nanosecond timescale are compared using neutron scattering. Surprisingly, both groups display similar dynamics as a function of temperature, and the buried hydrophobic core is sensitive to hydration and undergoes a dynamical transition. |
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Authors:
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Kathleen Wood; François-Xavier Gallat; Renee Otten; Auke J van Heel; Mathilde Lethier; Lambert van Eijck; Martine Moulin; Michael Haertlein; Martin Weik; Frans A A Mulder |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-14 |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: - ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Australian Nuclear Science and Technology Organisation Bragg Institute, Menai NSW (Australia); Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, (The Netherlands). |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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