Document Detail

Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  22770932     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Protein supplementation has been proposed as an effective dietary strategy to augment the skeletal muscle adaptive response to prolonged resistance-type exercise training in elderly people. Our objective was to assess the impact of protein supplementation on muscle mass, strength, and physical performance during prolonged resistance-type exercise training in frail elderly men and women.
DESIGN/SETTING/PARTICIPANTS: A randomized, double-blind, placebo-controlled trial with 2 arms in parallel among 62 frail elderly subjects (78 ± 1 year). These elderly subjects participated in a progressive resistance-type exercise training program (2 sessions per week for 24 weeks) during which they were supplemented twice daily with either protein (2 * 15 g) or a placebo.
MEASUREMENTS: Lean body mass (DXA), strength (1-RM), and physical performance (SPPB) were assessed at baseline, and after 12 and 24 weeks of intervention.
RESULTS: Lean body mass increased from 47.2 kg (95% CI, 43.5-50.9) to 48.5 kg (95% CI, 44.8-52.1) in the protein group and did not change in the placebo group (from 45.7 kg, 95% CI, 42.1-49.2 to 45.4 kg, 95% CI, 41.8-48.9) following the intervention (P value for treatment × time interaction = .006). Strength and physical performance improved significantly in both groups (P = .000) with no interaction effect of dietary protein supplementation.
CONCLUSIONS: Prolonged resistance-type exercise training represents an effective strategy to improve strength and physical performance in frail elderly people. Dietary protein supplementation is required to allow muscle mass gain during exercise training in frail elderly people.
TRIAL REGISTRATION: identifier: NCT01110369.
Michael Tieland; Marlou L Dirks; Nikita van der Zwaluw; Lex B Verdijk; Ondine van de Rest; Lisette C P G M de Groot; Luc J C van Loon
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-07-06
Journal Detail:
Title:  Journal of the American Medical Directors Association     Volume:  13     ISSN:  1538-9375     ISO Abbreviation:  J Am Med Dir Assoc     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-02-19     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  100893243     Medline TA:  J Am Med Dir Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Medical Directors Association, Inc. Published by Elsevier Inc. All rights reserved.
Top Institute Food and Nutrition, Wageningen, The Netherlands.
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MeSH Terms
Dietary Proteins / administration & dosage*,  metabolism
Dietary Supplements*
Double-Blind Method
Exercise Therapy
Frail Elderly*
Muscle Strength / physiology*
Muscle, Skeletal / physiology*
Resistance Training*
Reg. No./Substance:
0/Dietary Proteins
Comment In:
J Am Med Dir Assoc. 2013 Jan;14(1):69-71   [PMID:  23131546 ]
J Am Med Dir Assoc. 2013 Jan;14(1):71-2   [PMID:  23158847 ]
J Am Med Dir Assoc. 2013 Jan;14(1):65-6   [PMID:  23128023 ]
J Am Med Dir Assoc. 2013 Jan;14(1):72-3   [PMID:  23123005 ]
J Am Med Dir Assoc. 2013 Jan;14(1):67-9   [PMID:  23131547 ]
J Am Med Dir Assoc. 2013 Feb;14(2):144-5   [PMID:  23206724 ]
J Am Med Dir Assoc. 2013 Jan;14(1):73-4   [PMID:  23128025 ]
J Am Med Dir Assoc. 2013 Jan;14(1):63-5   [PMID:  23098416 ]
J Am Med Dir Assoc. 2013 Jan;14(1):66-7   [PMID:  23123006 ]
J Am Med Dir Assoc. 2012 Oct;13(8):667-8   [PMID:  22951026 ]
J Am Med Dir Assoc. 2013 Jan;14(1):62-3   [PMID:  23031263 ]

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