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Protein Supplementation During Resistance-Type Exercise Training in the Elderly.
MedLine Citation:
PMID:  22968306     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Resistance training has been well established as an effective treatment strategy to increase skeletal muscle mass and strength in the elderly. We assessed whether dietary protein supplementation can further augment the adaptive response to prolonged resistance type exercise training in healthy, elderly men and women. METHODS: Healthy, elderly men (n=31; 70±1y) and women (n=29: 70±1y) were randomly assigned to a progressive, 24-wk resistance type exercise training program with or without additional protein supplementation (15 g/d). Muscle hypertrophy was assessed on a whole-body (DXA), limb (CT), and muscle fiber (biopsy) level. Strength was assessed regularly by one-repetition maximum (1RM) strength testing. Functional capacity was assessed with a sit-to-stand and handgrip test. RESULTS: 1RM strength increased by 45±6 vs 40±3% (women) and 41±4 vs 44±3% (men) in the placebo vs protein group, respectively (P<0.001), with no differences between groups. Leg muscle mass (women: 4±1 vs 3±1%, men: 3±1 vs 3±1%) and quadriceps cross-sectional area (women: 9±1 vs 9±1%, men: 9±1 vs 10±1%) increased similarly in the placebo vs protein groups (P<0.001). Type II muscle fiber size increased over time in both placebo and protein groups (25±13 vs 30±9 and 23±12 vs 22±10% in the women and men, respectively). Sit-to-stand improved by 18±2 and 19±2% in women and men, respectively (P<0.001). CONCLUSION: Prolonged resistance type exercise training increases skeletal muscle mass and strength, augments functional capacity, improves glycemia and lipidemia, and reduces blood pressure in healthy elderly men and women. Additional protein supplementation (15 g/d) does not further increase muscle mass, strength, and/or functional capacity.
Authors:
Marika Leenders; Lex B Verdijk; Letty van der Hoeven; Janneau van Kranenburg; Rachel Nilwik; Will Kwh Wodzig; Joan Mg Senden; Hans A Keizer; Luc Jc van Loon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-10
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Top Institute Food and Nutrition, Wageningen, the Netherlands 2Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, Maastricht, the Netherlands 3Department of Clinical Chemistry, Maastricht University Medical Centre+, Maastricht, The Netherlands.
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