Document Detail

Protein S and congenital protein S deficiency: the most frequent congenital thrombophilia in Japanese.
MedLine Citation:
PMID:  16026279     Owner:  NLM     Status:  MEDLINE    
Protein S is a natural anticoagulant. Congenital protein S (PS) deficiency is a confirmed risk factor of venous thromboembolism (DVT) which though occurs infrequently yet is a leading cause of maternal mortality and morbidity. Congenital PS deficiency may also be responsible for obstetric complications such as preeclampsia/eclampsia, recurrent fetal loss and intrauterine fetal restriction. Congenital PS deficiency has been identified in 1-7.5% of patients with DVT and in 0.03-0.13% general Caucasian population. However, Japanese people have higher prevalence both in VTE patients (12.7%) and general population (0.48-0.63%). Because PS deficiency is the most frequent congenital thrombophilia in Japanese people, Japanese obstetricians must understand this thrombophilia and also that women with PS deficiency have an increased risk of VTE and a necessity of prophylactic use of anticoagulant against recurrent VTE during pregnancy and puerperium. This article reviews the literature to understand PS and congenital PS deficiency, especially the association of this thrombophilia with pregnancy.
Tomoko Adachi
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Current drug targets     Volume:  6     ISSN:  1389-4501     ISO Abbreviation:  Curr Drug Targets     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-19     Completed Date:  2005-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960531     Medline TA:  Curr Drug Targets     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  585-92     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Aiiku Maternal and Child Health Center Aiiku Hospital, Tokyo, Japan.
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MeSH Terms
Blood Coagulation Disorders / genetics,  physiopathology
Delivery, Obstetric
Infant, Newborn
Japan / epidemiology
Pregnancy Complications, Hematologic / physiopathology
Protein S Deficiency / epidemiology,  genetics*,  physiopathology*
Thrombophilia / congenital*,  epidemiology,  genetics

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