Document Detail

Protein S and C4b-binding protein in fetal and neonatal blood.
MedLine Citation:
PMID:  2973346     Owner:  NLM     Status:  MEDLINE    
The levels of protein C, free protein S, C4b-binding protein and the distribution of total protein S between a free form and a conjugated form with C4b-binding protein, were measured in fetuses between 15 and 35 weeks of gestation, in newborns and in maternal blood throughout pregnancy. Fetal and newborn umbilical blood samples were obtained by cordocentesis; in the case of newborns, immediately after delivery. C4b-binding protein was detected in five out of seven newborns and in only three out of 20 fetuses. The fetuses (21, 24, 29 weeks, respectively) whose blood contained C4b-binding protein (10%, 29%, 12% of adult level, respectively), did not survive: the possible cause of death for one was given as viral infection; all three were severely deformed. Only free protein S was detected in fetal blood and the mean value was 40%. By contrast, the mean levels of protein C in the fetuses increased from 11% to 15.5% of adult levels with advancing gestation. We conclude that the relatively high levels of free protein S in fetal blood may contribute to its non-coagulability and compensate for the low protein C levels.
E Melissari; K H Nicolaides; M F Scully; V V Kakkar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  70     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-23     Completed Date:  1988-12-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
Thrombosis Research Unit, King's College School of Medicine and Dentistry, London.
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MeSH Terms
Carrier Proteins / blood*
Complement C4 / metabolism
Complement Inactivator Proteins*
Fetal Blood / analysis*,  immunology
Glycoproteins / blood*
Infant, Newborn
Protein C / analysis
Protein S
Reg. No./Substance:
0/Carrier Proteins; 0/Complement C4; 0/Complement Inactivator Proteins; 0/Glycoproteins; 0/Protein C; 0/Protein S

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