| Protein S, C and antithrombin deficiency: Association to myocardial infarction and thromboembolism in young. | |
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MedLine Citation:
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PMID: 22535347 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: The pathogenesis of myocardial infarction (MI) in young involves new factors including constitutional or acquired thrombophilia. Aim: To determine in patients ² 50 years, the association between coagulation factors deficiency, myocardial infarction and cardiovascular events during follow-up. Methods: Protein C (PC), PS and antithrombin (AT) were screened in 50 patients admitted for acute MI and in a healthy control group. Univariate and multivariate analysis were performed using SPSS 11.5 version. Results: PS and PC deficiency were associated to MI (respectively 24% vs 0%, p=0.001 and 14% vs 0%, p=0.016), independently for PC. No AT deficiency was detected in both groups. During followup, PS and C deficiency were predictive for venous thrombosis (p<0.05) and PS deficiency for pulmonary embolism. Conclusion: Protein C and S deficiency may play an important role in MI in young and also in thromboembolic complications during follow-up. Nevertheless, therapeutic implications remain controversial. |
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Authors:
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Neila Ben Romdhane; Hela Baccouche; Sonia Ammar; Sonia Mahjoub; Sonia Chabrak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: La Tunisie médicale Volume: 90 ISSN: 0041-4131 ISO Abbreviation: Tunis Med Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413766 Medline TA: Tunis Med Country: Tunisia |
Other Details:
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Languages: eng Pagination: 316-9 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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