Document Detail

Protein S, C and antithrombin deficiency: Association to myocardial infarction and thromboembolism in young.
MedLine Citation:
PMID:  22535347     Owner:  NLM     Status:  In-Data-Review    
Background: The pathogenesis of myocardial infarction (MI) in young involves new factors including constitutional or acquired thrombophilia. Aim: To determine in patients ² 50 years, the association between coagulation factors deficiency, myocardial infarction and cardiovascular events during follow-up. Methods: Protein C (PC), PS and antithrombin (AT) were screened in 50 patients admitted for acute MI and in a healthy control group. Univariate and multivariate analysis were performed using SPSS 11.5 version. Results: PS and PC deficiency were associated to MI (respectively 24% vs 0%, p=0.001 and 14% vs 0%, p=0.016), independently for PC. No AT deficiency was detected in both groups. During followup, PS and C deficiency were predictive for venous thrombosis (p<0.05) and PS deficiency for pulmonary embolism. Conclusion: Protein C and S deficiency may play an important role in MI in young and also in thromboembolic complications during follow-up. Nevertheless, therapeutic implications remain controversial.
Neila Ben Romdhane; Hela Baccouche; Sonia Ammar; Sonia Mahjoub; Sonia Chabrak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  La Tunisie médicale     Volume:  90     ISSN:  0041-4131     ISO Abbreviation:  Tunis Med     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413766     Medline TA:  Tunis Med     Country:  Tunisia    
Other Details:
Languages:  eng     Pagination:  316-9     Citation Subset:  IM    
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