| Protein Nutrition Index as a Function of Patient Survival Rate in Peritoneal Dialysis. | |
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MedLine Citation:
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PMID: 20571279 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background/Aims: Protein-energy wasting (PEW) is a well-known risk factor of long-term survival in peritoneal dialysis (PD) patients. Serum albumin is a measure of visceral protein, lean body mass is a measure of somatic protein stores and normalized protein nitrogen appearance is a measure of daily protein intake. A protein nutrition index (PNI) that combined these 3 factors was designed and tested as a function of survival in PD patients. Methods: We enrolled 552 PD patients for this study. Demographic, biochemical, nutritional markers, comorbidity and dialysis-related data were obtained. The PNI was calculated. All patients were followed up to investigate the risks for mortality. Results: Patients with probable PEW/low-average nutrition were older and had lower serum creatinine (Cr) and blood urea nitrogen, lower adequacy data and higher D4/P4 Cr compared with patients with high-average/good nutrition. 108 patients (19.6%) died during the observational period. By multivariate analysis, we found only age, comorbidity index and PNI (relative risk = 0.84, confidence interval: 0.76-0.93, p = 0.001) to be independent predictors of mortality. Conclusion: The PNI at the start of PD is associated with all-cause mortality, and each increase by a score of 1 in PNI leads to a 16% decrease in the risk of mortality. Predialysis evaluation of this scoring system is recommended for further research in order to improve outcomes in PD patients. |
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Authors:
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Kuan-Hsing Chen; Ching-Herng Wu; Ching-Wei Hsu; Yu-Ming Chen; Shu-Man Weng; Chih-Wei Yang; Cheng-Chieh Hung |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-6-23 |
Journal Detail:
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Title: Kidney & blood pressure research Volume: 33 ISSN: 1423-0143 ISO Abbreviation: - Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-7-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610505 Medline TA: Kidney Blood Press Res Country: - |
Other Details:
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Languages: ENG Pagination: 174-180 Citation Subset: - |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Division of Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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