Document Detail


Protein kinase Cα as a heart failure therapeutic target.
MedLine Citation:
PMID:  20937286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure afflicts ~5 million people and causes ~300,000 deaths a year in the United States alone. Heart failure is defined as a deficiency in the ability of the heart to pump sufficient blood in response to systemic demands, which results in fatigue, dyspnea, and/or edema. Identifying new therapeutic targets is a major focus of current research in the field. We and others have identified critical roles for protein kinase C (PKC) family members in programming aspects of heart failure pathogenesis. More specifically, mechanistic data have emerged over the past 6-7 years that directly implicate PKCα, a conventional PKC family member, as a nodal regulator of heart failure propensity. Indeed, deletion of the PKCα gene in mice, or its inhibition in rodents with drugs or a dominant negative mutant and/or inhibitory peptide, has shown dramatic protective effects that antagonize the development of heart failure. This review will weigh all the evidence implicating PKCα as a novel therapeutic target to consider for the treatment of heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."
Authors:
Qinghang Liu; Jeffery D Molkentin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-16
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  51     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2012-01-06     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  474-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Evaluation, Preclinical
Gene Expression
Heart Failure / drug therapy*,  enzymology
Humans
Mice
Mice, Knockout
Molecular Targeted Therapy*
Myocardial Contraction
Myocardium / enzymology
Protein Kinase C-alpha / antagonists & inhibitors,  genetics,  metabolism*
Protein Kinase Inhibitors / therapeutic use
Grant Support
ID/Acronym/Agency:
R01 HL062927/HL/NHLBI NIH HHS; R01 HL062927-13/HL/NHLBI NIH HHS; R01 HL105924/HL/NHLBI NIH HHS; R01 HL105924-02/HL/NHLBI NIH HHS; R37 HL060562-15/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Protein Kinase Inhibitors; EC 2.7.11.13/Protein Kinase C-alpha
Comments/Corrections

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