| Protein Degradation Pathways after Brain Ischemia. | |
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MedLine Citation:
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PMID: 22204315 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There are two major routes for clearance of aberrant cellular components: (i) the ubiquitin-proteasomal system (UPS); and (ii) the autophagy pathway. The UPS degrades individual abnormal proteins, whereas the autophagy pathway is the chief route for bulk degradation of large abnormal protein aggregates and aberrant organelles. Impairments of the protein degradation pathways are closely tied with many human diseases. For example, brain ischemia leads to protein misfolding and aggregation, resulting in overproduction of protein aggregate-associated organelles. Brain ischemia also damages protein degradation pathways. As a result, damaged organelles overproduced in postischemic neurons are unable to be eliminated. This chapter will discuss molecular mechanisms underlying the impairments of the UPS and autophagy pathways and how such impairments lead to multiple organelle failure and delayed neuronal death after brain ischemia. |
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Authors:
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Chunli Liu; Pengfei Ge; Liankun Sun; Jiang Wu; Kang-Fu Kang Sun; Bingren Hu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
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Title: Current drug targets Volume: - ISSN: 1873-5592 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Phathphysiology, Neurology and Neurosurgery, First Teaching Hospital, Jilin University, Changchun, China. bhu@anes.umm.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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