Document Detail

Protein C, protein S, and thrombomodulin in amniotic fluid. A preliminary study.
MedLine Citation:
PMID:  16856817     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The main components of protein C anticoagulant system are protein C (PC), protein S (PS) and thrombomodulin (TM); the system plays a protective role in pregnancy, mainly because it prevents the utero-placental circulation from local thrombosis. It is unknown whether the protein C anticoagulant pathway exists in amniotic fluid. The aim of the present study is to find out whether these three components are present in amniotic fluid. STUDY DESIGN: The study group consisted of 50 parturients with an uneventful pregnancy and birth and 25 non-pregnant controls. Amniotic fluid and blood were sampled at the end of the 1st stage of labor. PC, PS and TM were measured by immunoenzymatic method. RESULTS: All the samples of amniotic fluid contained measurable amounts of antigens of PC, PS and TM, although their concentrations were significantly lower than in the mother's blood: (i) The concentration of PC in amniotic fluid was 6.24+/-3.50% and PS 2.40+/-1.64%, while in the mothers' plasma it was 138.26+/-12.38% and 93.15+/-13.24%, respectively (P<0.0001). (ii) TM concentration in amniotic fluid constituted 63.92% of the concentration in the mother's blood (2.71+/-1.21 ng/mL vs. 4.24+/-0.88 ng/mL, P<0.001). CONCLUSION: Protein C, protein S and thrombomodulin are physiological constituents of the amniotic fluid. As their concentrations are low, it is reasonable to assume that they cannot counterbalance the procoagulant activity of amniotic fluid.
Mieczysław Uszyński; Ewa Zekanowska; Marcin Kotzbach; Waldemar Uszyński; Roman Kotzbach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  34     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-21     Completed Date:  2007-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  289-92     Citation Subset:  IM    
Department of Propedeutics of Medicine, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland.
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MeSH Terms
Amniotic Fluid / chemistry*
Blood Coagulation / physiology
Case-Control Studies
Labor Stage, First / blood,  metabolism
Protein C / analysis*
Protein S / analysis*
Thrombomodulin / analysis*,  blood
Reg. No./Substance:
0/Protein C; 0/Protein S; 0/Thrombomodulin

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