| Protein C, protein S, and thrombomodulin in amniotic fluid. A preliminary study. | |
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MedLine Citation:
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PMID: 16856817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The main components of protein C anticoagulant system are protein C (PC), protein S (PS) and thrombomodulin (TM); the system plays a protective role in pregnancy, mainly because it prevents the utero-placental circulation from local thrombosis. It is unknown whether the protein C anticoagulant pathway exists in amniotic fluid. The aim of the present study is to find out whether these three components are present in amniotic fluid. STUDY DESIGN: The study group consisted of 50 parturients with an uneventful pregnancy and birth and 25 non-pregnant controls. Amniotic fluid and blood were sampled at the end of the 1st stage of labor. PC, PS and TM were measured by immunoenzymatic method. RESULTS: All the samples of amniotic fluid contained measurable amounts of antigens of PC, PS and TM, although their concentrations were significantly lower than in the mother's blood: (i) The concentration of PC in amniotic fluid was 6.24+/-3.50% and PS 2.40+/-1.64%, while in the mothers' plasma it was 138.26+/-12.38% and 93.15+/-13.24%, respectively (P<0.0001). (ii) TM concentration in amniotic fluid constituted 63.92% of the concentration in the mother's blood (2.71+/-1.21 ng/mL vs. 4.24+/-0.88 ng/mL, P<0.001). CONCLUSION: Protein C, protein S and thrombomodulin are physiological constituents of the amniotic fluid. As their concentrations are low, it is reasonable to assume that they cannot counterbalance the procoagulant activity of amniotic fluid. |
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Authors:
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Mieczysław Uszyński; Ewa Zekanowska; Marcin Kotzbach; Waldemar Uszyński; Roman Kotzbach |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 34 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 2006 |
Date Detail:
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Created Date: 2006-07-21 Completed Date: 2007-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 289-92 Citation Subset: IM |
Affiliation:
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Department of Propedeutics of Medicine, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland. kizproped@cm.umk.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / chemistry* Blood Coagulation / physiology Case-Control Studies Female Humans Labor Stage, First / blood, metabolism Pregnancy Protein C / analysis* Protein S / analysis* Thrombomodulin / analysis*, blood |
| Chemical | |
Reg. No./Substance:
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0/Protein C; 0/Protein S; 0/Thrombomodulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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