Document Detail

Protein C activator from the venom of Agkistrodon blomhoffi ussuriensis retards thrombus formation in the arterio-venous shunt in rats.
MedLine Citation:
PMID:  8378894     Owner:  NLM     Status:  MEDLINE    
Protein C (PC) is an anticoagulant protein which, being activated by thrombin, degrades factors V/Va and VIII/VIIIa and releases a tissue-type plasminogen activator. Some Agkistrodon snake venoms contain PC activators which, in experiments, exert an anticoagulant action. An antithrombotic effect of the PC activator from the venom of A. blomhoffi ussuriensis on the model of thrombus formation in the arterio-venous shunt in rats was under investigation. Administration of the PC activator resulted in a dose-dependent prolongation of the thrombus formation time and a decrease in plasma PC activity, which were accompanied by a decrease in factor V activity and APTT prolongation. No reliable changes in the t-PA level, ADP- and epinephrine-induced platelet aggregation were observed. Platelet adhesion to glass beads diminished. We assume that the antithrombotic effect of the PC activator from the A. blomhoffi venom in the platelet-dependent thrombosis model is caused by PC activation and subsequent factor V inactivation as well as by platelet adhesiveness reduction.
A E Kogan; G V Bashkov; I D Bobruskin; E P Romanova; V A Makarov; S M Strukova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  70     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-20     Completed Date:  1993-10-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-93     Citation Subset:  IM    
Laboratory of Blood Coagulation, Moscow State University, Russia.
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MeSH Terms
Amino Acid Sequence
Arteriovenous Shunt, Surgical*
Blood Coagulation / drug effects*
Chromatography, High Pressure Liquid
Crotalid Venoms / chemistry*
Dose-Response Relationship, Drug
Enzyme Activation / drug effects
Factor V / metabolism
Fibrinolytic Agents / pharmacology*,  therapeutic use
Molecular Sequence Data
Partial Thromboplastin Time
Peptides / isolation & purification,  pharmacology*,  therapeutic use
Platelet Adhesiveness / drug effects
Platelet Aggregation / drug effects
Protein C / metabolism*
Rats, Wistar
Species Specificity
Thrombosis / prevention & control*
Reg. No./Substance:
0/Crotalid Venoms; 0/Fibrinolytic Agents; 0/Peptides; 0/Protein C; 0/snake venom protein C activator; 9001-24-5/Factor V

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