Document Detail

Protein C abnormalities in spinal cord injured patients with end-stage renal disease.
MedLine Citation:
PMID:  3675178     Owner:  NLM     Status:  MEDLINE    
Patients with chronic spinal cord injury (SCI) and end-stage renal disease (ESRD) exhibit antithrombin III deficiency and several other coagulation abnormalities. In view of increasing recognition of protein C (PC) as an important, naturally occurring anticoagulant and fibrinolytic factor, we studied plasma PC in this population. PC antigen concentration and its anticoagulant activity were measured in nine SCI men with ESRD maintained on hemodialysis and in a control group of ten normal able-bodied men. The results showed a significant increase in PC anticoagulant activity in the SCI group. Consequently, the ratio of the PC activity to its concentration, which is a measure of the functional integrity of PC molecule, was markedly depressed. These findings are indicative of the presence of inactive or abnormal PC in SCI-ESRD patients and may suggest its in vivo activation. The combination of impaired PC activity shown in this study, with previously demonstrated antithrombin III deficiency and other coagulation abnormalities, is suggestive of a hypercoagulable state.
N D Vaziri; B Patel; A E Gonzales; R L Winer; I Eltorai; S Gordon; K Danviryasup
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  68     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-14     Completed Date:  1987-12-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  791-3     Citation Subset:  AIM; IM    
Department of Medicine, University of California, Irvine 92668.
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MeSH Terms
Blood Coagulation Tests
Kidney Failure, Chronic / blood*,  etiology
Middle Aged
Protein C / analysis*
Renal Dialysis
Spinal Cord Injuries / blood*,  complications
Reg. No./Substance:
0/Protein C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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