Document Detail

Protein C and D-dimer are related to portal vein thrombosis in patients with liver cirrhosis.
MedLine Citation:
PMID:  19686413     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: To profile changes of coagulation, anticoagulation and fibrolytic factors associated with liver function failure and portal vein thrombosis (PVT) formation in chronic liver cirrhosis patients. METHODS: A total of 116 cirrhotic patients admitted to our hospital from June 2006 to October 2008 were included in our study. All patients were classified into two groups: PVT group (31 patients), composed of patients with PVT and a control group (85 patients), including patients without PVT. Platelet, prothrombin time (PT), activated partial prothrombin time (APTT) and fibrinogen were measured. Also, plasma samples from the patients were analyzed for the levels of antithrombin III (AT-III), protein C (PC), protein S (PS), D-dimer, tissue-type plasminogen activator as well as plasminogen activator inhibitor-1. Statistical analyses were carried out to evaluate the correlation of specific variations with the disease status. RESULTS: In general, the higher Child-Pugh scores, indicating the aggravation of hepatic impairment of the patients, correlated well with the prolonged PT/APTT and increased D-dimer, as well as decreased platelet, fibrinogen, PC and AT-III levels in the serum. Furthermore, we found that the PC, PS and D-dimer levels in PVT patients were 2.32 +/- 0.72 mg/L, 17.14 +/- 3.62 mg/L and 0.99 +/- 0.36 mg/L, respectively, both representing a significant difference compared with those in the control group without PVT. Logistic regression model shows that the odds ratio value of one unit of increase of PC and D-dimer were 0.48 and 15.57. CONCLUSIONS: Cirrhotic patients displayed dysfunctions in the coagulation, anti-coagulation and fibrolytic systems. The development of PVT in these patients may be independently associated with the decrease of PC, PS and D-dimer. Furthermore, decreasing PC and increasing D-dimer may be risk factors inducing PVT in cirrhotic patients.
Donglei Zhang; Jianyu Hao; Ning Yang
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Publication Detail:
Type:  Journal Article     Date:  2009-08-03
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  25     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  116-21     Citation Subset:  IM    
Beijing Chaoyang Hospital Affiliate of Capital Medical University, Department of Gastroenterology, Beijing, China.
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MeSH Terms
Antithrombin III / analysis
Biological Markers / blood
Blood Coagulation*
Case-Control Studies
Chronic Disease
Fibrin Fibrinogen Degradation Products / analysis*
Liver Cirrhosis / blood*,  complications
Logistic Models
Middle Aged
Odds Ratio
Partial Thromboplastin Time
Platelet Count
Portal Vein*
Protein C / analysis*
Protein S / analysis
Prothrombin Time
Risk Assessment
Risk Factors
Venous Thrombosis / blood,  etiology*
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/Protein C; 0/Protein S; 0/fibrin fragment D; 9000-94-6/Antithrombin III
Comment In:
J Gastroenterol Hepatol. 2010 Jan;25(1):1-2   [PMID:  20136967 ]

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