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Protein Biomarkers Identify Patients Unlikely to Benefit from Primary Prevention ICDs: Findings from the PROSE-ICD Study.
MedLine Citation:
PMID:  25273351     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -Primary prevention implantable cardioverter defibrillators (ICDs) reduce all-cause mortality but the benefits are heterogeneous. Current risk stratification based on left ventricular ejection fraction has limited discrimination power. We hypothesize that biomarkers for inflammation, neurohumoral activation and cardiac injury can predict appropriate shocks and all-cause mortality in patients with primary prevention ICDs.
METHODS AND RESULTS: -The Prospective Observational Study of Implantable Cardioverter Defibrillators (PROSe-ICD) enrolled 1,189 patients with systolic heart failure who underwent ICD implantation for primary prevention of sudden cardiac death. The primary endpoint was an ICD shock for adjudicated ventricular tachyarrhythmia. The secondary endpoint was all-cause mortality. After a median follow-up of 4.0 years, 137 subjects experienced an appropriate ICD shock and 343 participants died (incidence rates of 3.2 and 5.8 per 100 person-years, respectively). In multivariable adjusted models, higher interleukin-6 (IL-6) levels increased the risk of appropriate ICD shocks. In contrast, C-reactive protein, IL-6, tumor necrosis factor-α receptor II, pro-brain natriuretic peptide, and cardiac troponin T showed significant linear trends for increased risk of all-cause mortality across quartiles. A score combining these 5 biomarkers identified patients who were much more likely to die than to receive an appropriate shock from the ICD.
CONCLUSIONS: -An increase in serum biomarkers of inflammation, neurohumoral activation and myocardial injury increased the risk for death but poorly predicted the likelihood of an ICD shock. These findings highlight the potential importance of serum-based biomarkers in identifying patients who are unlikely to benefit from primary prevention ICDs. Clinical Trial Registration-clinicaltrials.gov; Unique Identifier: NCT00733590.
Authors:
Alan Cheng; Yiyi Zhang; Elena Blasco-Colmenares; Darshan Dalal; Barbara Butcher; Sanaz Norgard; Zayd Eldadah; Kenneth A Ellenbogen; Timm Dickfeld; David D Spragg; Joseph E Marine; Eliseo Guallar; Gordon F Tomaselli
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-1
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-2     Completed Date:  -     Revised Date:  2014-10-3    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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