| Protein-based MRI contrast agents for molecular imaging of prostate cancer. | |
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MedLine Citation:
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PMID: 20574851 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to demonstrate a novel protein-based magnetic resonance imaging (MRI) contrast agent that has the capability of targeting prostate cancer and which provides high-sensitivity MR imaging in tumor cells and mouse models. PROCEDURE: A fragment of gastrin-releasing peptide (GRP) was fused into a protein-based MRI contrast agent (ProCA1) at different regions. MR imaging was obtained in both tumor cells (PC3 and H441) and a tumor mouse model administrated with ProCA1.GRP. RESULTS: PC3 and DU145 cells treated with ProCA1.GRPs exhibited enhanced signal in MRI. Intratumoral injection of ProCA1.GRP in a PC3 tumor model displayed enhanced MRI signal. The contrast agent was retained in the PC3 tumor up to 48 h post-injection. CONCLUSIONS: Protein-based MRI contrast agent with tumor targeting modality can specifically target GRPR-positive prostate cancer. Intratumoral injection of the ProCA1 agent in the prostate cancer mouse model verified the targeting capability of ProCA1.GRP and showed a prolonged retention time in tumors. |
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Authors:
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Lixia Wei; Shunyi Li; Jianhua Yang; Yiming Ye; Jin Zou; Liya Wang; Robert Long; Omar Zurkiya; Tiejun Zhao; Julian Johnson; Jingjuan Qiao; Wangda Zhou; Adriana Castiblanco; Natalie Maor; Yanyi Chen; Hui Mao; Xiaoping Hu; Jenny J Yang; Zhi-Ren Liu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 13 ISSN: 1860-2002 ISO Abbreviation: Mol Imaging Biol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 416-23 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Biology, Georgia State University, Atlanta, GA, 30302, USA. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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