Document Detail

Protective role of trace metals in lead intoxication.
MedLine Citation:
PMID:  7179308     Owner:  NLM     Status:  MEDLINE    
Protective effect of copper (Cu), zinc (Zn) or cobalt (Co) against lead (Pb) toxicity in rats was investigated. Trace metal administration together with Pb decreased the hepatic and renal uptake of lead and reduced the Pb-induced inhibition of blood delta-aminolevulinic acid dehydratase (delta-ALAD) activity. The hepatic uptake of Zn or Co was also increased in animals administered Pb and Zn or Pb and Co, respectively. However, no significant difference could be observed between the protective effects of three essential trace metals examined against lead toxicity.
S J Flora; V K Jain; J R Behari; S K Tandon
Related Documents :
22020578 - Delayed healing and induction of secretory leukocyte protease inhibitor in polycystic o...
6481488 - Zinc deficiency-induced changes in rat parotid salivary proteins.
10656628 - The effects of dietary iron overload on fumonisin b1-induced cancer promotion in the ra...
2841778 - Synergistic enhancement of the biliary excretion of cadmium by the simultaneous adminis...
9065488 - Monoamine oxidase inhibition causes a long-term prolongation of the dopamine-induced re...
11106878 - Augmented accumbal serotonin levels decrease the preference for a morphine associated e...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  13     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cobalt / pharmacology
Copper / pharmacology
Kidney / metabolism
Lead / metabolism
Lead Poisoning / prevention & control*
Liver / metabolism
Trace Elements / pharmacology*
Zinc / pharmacology
Reg. No./Substance:
0/Trace Elements; 7439-92-1/Lead; 7440-48-4/Cobalt; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A rapid procedure to efficiently clean blenders repeatedly used to prepare dosed feed for bioassays.
Next Document:  Acetone potentiation of 1,1,2-trichloroethane hepatotoxicity.