Document Detail

Protective role of trace metals in lead intoxication.
MedLine Citation:
PMID:  7179308     Owner:  NLM     Status:  MEDLINE    
Protective effect of copper (Cu), zinc (Zn) or cobalt (Co) against lead (Pb) toxicity in rats was investigated. Trace metal administration together with Pb decreased the hepatic and renal uptake of lead and reduced the Pb-induced inhibition of blood delta-aminolevulinic acid dehydratase (delta-ALAD) activity. The hepatic uptake of Zn or Co was also increased in animals administered Pb and Zn or Pb and Co, respectively. However, no significant difference could be observed between the protective effects of three essential trace metals examined against lead toxicity.
S J Flora; V K Jain; J R Behari; S K Tandon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  13     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
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MeSH Terms
Cobalt / pharmacology
Copper / pharmacology
Kidney / metabolism
Lead / metabolism
Lead Poisoning / prevention & control*
Liver / metabolism
Trace Elements / pharmacology*
Zinc / pharmacology
Reg. No./Substance:
0/Trace Elements; 7439-92-1/Lead; 7440-48-4/Cobalt; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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