Document Detail


Protective role of intracoronary fatty acid binding protein in ischemic and reperfused myocardium.
MedLine Citation:
PMID:  2111739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, fatty acid binding protein was used to protect an ischemic heart from reperfusion injury. Isolated rat heart was preperfused in the presence of 1.4 microM liposome-bound fatty acid binding protein for 15 minutes, followed by 30 minutes of ischemia and 30 minutes of reperfusion. Our results indicated better preservation of myocardial high-energy phosphate compounds (including ATP and creatine phosphate), reduced creatine kinase and lactate dehydrogenase release from the heart, and improved coronary flow in hearts treated with fatty acid binding protein compared with untreated controls. Fatty acid binding protein enhanced reacylation of arachidonic acid into phospholipids, thereby preserving membrane phospholipids and reducing free fatty acid contents during ischemia and reperfusion. In addition, fatty acid binding protein-bound long-chain free fatty acids and their thioesters as well as carnitine esters were increased in the cytosolic compartment of the heart. These results suggest that fatty acid binding protein may be used as a possible therapeutic agent to improve myocardial function during reperfusion of ischemic heart.
Authors:
B N Srimani; R M Engelman; R Jones; D K Das
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  66     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-05     Completed Date:  1990-07-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1535-43     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Connecticut School of Medicine, Farmington 06032.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid
Arachidonic Acids / pharmacokinetics
Carrier Proteins / pharmacology*
Coronary Circulation / drug effects
Coronary Disease / physiopathology*
Creatine Kinase / metabolism
Fatty Acid-Binding Proteins
Fatty Acids / metabolism
Heart / physiopathology
L-Lactate Dehydrogenase / metabolism
Lipid Peroxides / metabolism
Myocardial Reperfusion*
Myocardium / metabolism
Neoplasm Proteins*
Nerve Tissue Proteins*
Perfusion
Phosphates / metabolism
Phospholipids / biosynthesis
Rats
Grant Support
ID/Acronym/Agency:
HL-22559/HL/NHLBI NIH HHS; HL-33889/HL/NHLBI NIH HHS; HL-34360/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Carrier Proteins; 0/Fabp7 protein, rat; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids; 0/Lipid Peroxides; 0/Neoplasm Proteins; 0/Nerve Tissue Proteins; 0/Phosphates; 0/Phospholipids; 506-32-1/Arachidonic Acid; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.3.2/Creatine Kinase
Comments/Corrections
Comment In:
Circ Res. 1991 May;68(5):1490-1   [PMID:  2019004 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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