Document Detail

Protective role of immobilization on ouabain-induced arrhythmias.
MedLine Citation:
PMID:  9500127     Owner:  NLM     Status:  MEDLINE    
The effects of the opioid-type stressor, immobilization, on severity of ouabain-induced cardiac arrhythmias and the possible involvement of serum catecholamines were investigated in rats. Immobilization significantly reduced the number of ventricular premature beats and the incidence of ventricular tachycardia episodes. The arterial serum catecholamine levels (A, NA and DA), measured immediately after the stressor application, were increased significantly and were in negative correlation with the arrhythmia parameters. Both changes were reversed by naloxone (5 mg/kg) treatment after application of immobilization. The effects observed in this study may be attributed to the actions of endogenous opioid peptides released during stress.
Y Uresin; L Eroglu; G Yildiran; B Güvener; E Ozkok
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  19     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-04-27     Completed Date:  1998-04-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  633-6     Citation Subset:  IM; S    
Istanbul University, Istanbul Medical Faculty, Department of Pharmacology and Clinical Pharmacology, Capa, Turkey.
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MeSH Terms
Anti-Arrhythmia Agents
Arrhythmias, Cardiac / blood,  chemically induced,  therapy*
Dopamine / blood
Epinephrine / blood
Heart Rate
Immobilization / physiology*
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Norepinephrine / blood
Opioid Peptides / metabolism*
Rats, Wistar
Stress, Physiological / metabolism*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Narcotic Antagonists; 0/Opioid Peptides; 465-65-6/Naloxone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 630-60-4/Ouabain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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