| Protective role of glibenclamide against nicotinamide-streptozotocin induced nuclear damage in diabetic Wistar rats. | |
| | |
MedLine Citation:
|
PMID: 21808586 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the protective effect of glibenclamide against the experimental diabetes-induced nuclear damage in Wistar rats. MATERIALS AND METHODS: The anti-mutagenic effect of glibenclamide (0.5, 5 and 50 mg/kg, p.o daily for 4 weeks) was evaluated against the nicotinamide (NA)-streptozotocin (STZ) induced type-2 diabetes mellitus using bone marrow micronucleus and sperm abnormalities tests. The antioxidant status was tested by estimating the serum levels of lipid peroxidation (LPO), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx). RESULTS: The results indicated that glibenclamide at 50 mg/kg decreased the frequency of micronuclei in erythrocytes (P < 0.05) and sperm shape abnormality (P < 0.01) besides enhancing the antioxidant status (P < 0.05) in the diabetic rats. However, glibenclamide treatment did not enhance the polychromatic and normochromatic erythrocytes (P/N) ratio and sperm count in the diabetic condition. CONCLUSION: The observations indicate that the glibenclamide has anti-mutagenic potential which could be related to the antioxidant effect and might also possess anti-proliferative property. |
| | |
Authors:
|
Syed Imam Rabbani; Kshama Devi; Salma Khanam |
Related Documents
:
|
16342516 - Analysis of the chaotic component of the sinusal r-r intervals as a tool for detecting ... 7924876 - Effect of actual glycaemia on pupillary function in children with type 1 diabetes. 12686166 - Impaired 0.1-hz vasomotion assessed by laser doppler anemometry as an early index of pe... 7957506 - Influence of digoxin-like immunoreactive factor on late complications in patients with ... 20528716 - Dose adjustment for normal eating (dafne) - an audit of outcomes in australia. 15934886 - Cost-effectiveness of oral hypoglycaemic agents for the treatment of type 2 diabetes me... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of pharmacology & pharmacotherapeutics Volume: 1 ISSN: 0976-5018 ISO Abbreviation: J Pharmacol Pharmacother Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2011-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101552113 Medline TA: J Pharmacol Pharmacother Country: India |
Other Details:
|
Languages: eng Pagination: 18-23 Citation Subset: - |
Affiliation:
|
Department of Pharmacology, Al-Ameen College of Pharmacy, Opp. Lalbagh Main Gate, Hosur Road, Bangalore-560 027, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adipocytokines: The pied pipers.
Next Document: Effect of vitamin E alone and in combination with lycopene on biochemical and histopathological alte...