| Protective role of chrysin against oxidative stress in d-galactose-induced aging in an experimental rat model. | |
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MedLine Citation:
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PMID: 22469068 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To evaluate the putative protective role of chrysin, an isoflavone, on d-galactose-induced aging in an experimental rat model. Methods: Rats were divided into five groups of five each. Group I received 0.9% saline only. Groups II, III and IV received d-galactose (50 mg/kg bodyweight) intraperitoneally, additionally group III and group IV received chrysin (20 mg/kg bodyweight) and α-tocopherol acetate (200 mg/kg bodyweight), respectively. Group V received chrysin alone. The experiment period was for a period of 8 weeks. After the rats were killed, the tissue samples were analyzed for mean activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, glucose-6-phosphate dehydrogenase, reduced glutathione, vitamin C, vitamin E, malondialdehyde and protein carbonyl. Histopathological studies were also carried out for morphological conformation. Results: Tissue samples from d-galactose-exposed untreated rats showed significantly (P < 0.05) lower levels of enzymatic and non-enzymatic anti-oxidants, and significantly (P < 0.05) higher levels of malondialdehyde and protein carbonyl when compared with group I and group III rats. Oral administration of chrysin for a period of 8 weeks, concomitant with the exposure to d-galactose, appeared to protect against oxidative damage and maintained all parameters at near normal levels. Histopathological studies confirmed the oxidative damage caused by d-galactose alone in tissues and also showed the tissue protective role of chrysin in rats receiving d-galactose and chrysin. Conclusion: These results suggest that chrysin protects against oxidative stress-induced tissue damage in d-galactose-induced aging in an experimental rat model. Geriatr Gerontol Int 2012; ••: ••-••. |
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Authors:
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Kalaiselvi Velayutham Anand; Mohamed Sultan Mohamed Jaabir; Philip A Thomas; Pitchairaj Geraldine |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-2 |
Journal Detail:
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Title: Geriatrics & gerontology international Volume: - ISSN: 1447-0594 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135738 Medline TA: Geriatr Gerontol Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Japan Geriatrics Society. |
Affiliation:
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Department of Animal Science, School of Life Sciences, Bharathidasan University Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirappalli, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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