Document Detail


Protective role of Phaseolus vulgaris on changes in the fatty acid composition in experimental diabetes.
MedLine Citation:
PMID:  15298769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present investigation was carried out to evaluate the effect of Phaseolus vulgaris, an indigenous plant used in Unani and Ayurvedic medicine in India, on blood glucose, plasma insulin, cholesterol, triglycerides, free fatty acids, phospholipids, and fatty acid composition of total lipids in liver, kidney, and brain of normal and streptozotocin (STZ) diabetic rats. The results show that there was a significant increase in tissue cholesterol, triglycerides, free fatty acids, and phospholipids in STZ diabetic rats. The analysis of fatty acids showed that there was a significant increase in the concentrations of palmitic acid (16:1), stearic acid (18:0), and oleic acid (18:1) in liver, kidney, and brain, whereas the concentrations of linolenic acid (18:3) and arachidonic acid (20:4) were significantly decreased. Oral administration of the aqueous extract of P. vulgaris pods (200 mg/kg of body weight) for 45 days to diabetic rats decreased the concentrations of lipids and fatty acids, viz., palmitic, stearic, and oleic acids, whereas linolenic and arachidonic acids were elevated. Similarly, the administration of P. vulgaris pod extract (PPEt) to normal animals resulted in a significant hypolipidemic effect. These results suggest that PPEt exhibits hypoglycemic and hypolipidemic effects in STZ diabetic rats. It also prevents the fatty acid changes produced during diabetes. The effect of PPEt at 200 mg/kg of body weight was better than that of glibenclamide.
Authors:
Leelavinothan Pari; Subramanian Venkateswaran
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal food     Volume:  7     ISSN:  1096-620X     ISO Abbreviation:  J Med Food     Publication Date:  2004  
Date Detail:
Created Date:  2004-08-09     Completed Date:  2004-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India. paribala@sancharnet.in
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid / analysis
Blood Glucose / analysis
Brain Chemistry
Cholesterol / analysis
Diabetes Mellitus, Experimental / drug therapy,  metabolism*
Fatty Acids / analysis*
Glyburide / administration & dosage
Insulin / blood
Kidney / chemistry
Liver / chemistry
Male
Oleic Acid / analysis
Palmitic Acid / analysis
Phaseolus / chemistry*
Phytotherapy*
Plant Extracts / administration & dosage*
Rats
Rats, Wistar
Stearic Acids / analysis
Triglycerides / analysis
alpha-Linolenic Acid / analysis
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids; 0/Plant Extracts; 0/Stearic Acids; 0/Triglycerides; 10238-21-8/Glyburide; 11061-68-0/Insulin; 112-80-1/Oleic Acid; 463-40-1/alpha-Linolenic Acid; 506-32-1/Arachidonic Acid; 57-10-3/Palmitic Acid; 57-11-4/stearic acid; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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