Document Detail


Protective mechanisms against oxidative stress and angiopathy in young patients with diabetes type 1 (DM1).
MedLine Citation:
PMID:  23337054     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: Advanced glycation end-products (AGEs) via their receptor, RAGE, are involved in diabetic angiopathy. Soluble RAGE, an inhibitor of this axis, is formed by enzymatic catalysis (sRAGE) or alternative splicing (esRAGE). Malondialdehyde (MDA) is an oxidative stress marker, and ferric reducing ability of plasma (FRAP) is an anti-oxidant capacity marker. Methods: In isolated mononuclear blood cells from 110 DM1-patients (P) and 124 controls (C) (4-29 years) RAGE mRNA (g) and protein expression (pe) were measured by RT-PCR and Western immunoblotting, respectively. Plasma levels of CML (AGEs) and sRAGE were measured by ELISA, MDA by flurometry and FRAP according to 'Benzie and Strain'. Results: P showed: (i) higher g of RAGE, especially in p>13 years of age and >5 years DM1, (ii) increased pe of esRAGE in DM1>5 years and (iii) increased FRAP and MDA. Conclusions: The increased esRAGE and FRAP with increased levels of CML and MDA possibly reflects a protective response against the formation of diabetic complications in these young diabetic patients.
Authors:
Nikolitsa Koutroumani; Ioanna Partsalaki; Fotini Lamari; Athina Dettoraki; Andrea Paola Rojas Gil; Alexia Karvela; Eirini Kostopoulou; Bessie E Spiliotis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  -     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-9     Citation Subset:  -    
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